Tremorine

Tremorine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine;
CAS Number	51-73-0;
PubChem CID	5534;
ChemSpider	5333;
CompTox Dashboard (EPA)	DTXSID00199004 ;
Chemical and physical data
Formula	C12H20N2
Molar mass	192.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C2CCCN2CC#CCN1CCCC1;
	InChI InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2; Key:JSUAJTLKVREZHV-UHFFFAOYSA-N;

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.^[1]^[2]^[3]^[4]^[5] Beta blockers are also effective in counteracting the effects of tremorine.^[6]

References

^ Trautner, E. M.; Gershon, S. (1959). "Use of 'Tremorine' for screening Anti-Parkinsonian Drugs". Nature. 183 (4673): 1462–1463. doi:10.1038/1831462a0. PMID 13657170.
^ Friedman, A. H.; Aylesworth, R. J.; Friedman, G. (1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science. 141 (3586): 1188–1190. doi:10.1126/science.141.3586.1188. PMID 14043364.
^ Menon, M.; Clark, W. G.; Aures, D. (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications. 3 (4): 345. doi:10.1016/0031-6989(71)90005-1.
^ Shinozaki, H.; Hirate, K.; Ishida, M. (1985). "Further studies on quantification of drug-induced tremor in mice: Effects of antitremorgenic agents on tremor frequency". Experimental neurology. 88 (2): 303–315. doi:10.1016/0014-4886(85)90193-1. PMID 3987859.
^ Morais, L.; Quintansjunior, L.; Franco, C.; Almeida, J.; Almeida, R. (2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology Biochemistry and Behavior. 79 (4): 745–749. doi:10.1016/j.pbb.2004.10.004. PMID 15582683.
^ Paul, V. (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: Antitremor effect of beta-adrenoceptor antagonists". Indian journal of physiology and pharmacology. 30 (4): 307–312. PMID 2883120.

References

See also