Trimethylthiazoline

Trimethylthiazoline
Names
	IUPAC name 2,4,5-Trimethyl-4,5-dihydro-1,3-thiazole
Identifiers
3D model (JSmol)	Interactive image;
PubChem CID	263626;
CompTox Dashboard (EPA)	DTXSID20294803 DTXSID50945917, DTXSID20294803 ;
	InChI InChI=1S/C6H11NS/c1-4-5(2)8-6(3)7-4/h4-5H,1-3H3 Key: CIEKNJJOENYFQL-UHFFFAOYSA-N;
	SMILES CC1C(SC(=N1)C)C;
Properties
Chemical formula	C6H11NS
Molar mass	129.22 g·mol−1
Appearance	Light yellow liquid
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). (what is ?) Infobox references

Trimethylthiazoline (TMT or 2,5-dihydro-2,4,5-trimethylthiazoline) is a constituent of fox urine that is an innately aversive odor to rodents. The chemical is liquid at room temperature and has a very light yellow color which darkens on oxygen exposure over time.

Research

Researchers at SRQBio were able to synthesize TMT and use it with a combination of other stressors such as foot shocks/loud noises as a natural predator psychogenic stress to study posttraumatic stress disorder in rodents.^[1] TMT has been called an "innate threat stimulus" because of how it "induces a number of fear and defensive behaviors" in naive mice and rats.^[2]

References

^ "Trimethylthiazoline (TMT - a component of fox feces/urine)".
^ Goswami, S; Rodríguez-Sierra, O (2013). "Animal models of post-traumatic stress disorder: face validity". Frontiers in Neuroscience. doi:10.3389/fnins.2013.00089.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] "Trimethylthiazoline (TMT - a component of fox feces/urine)".

[2] Goswami, S; Rodríguez-Sierra, O (2013). "Animal models of post-traumatic stress disorder: face validity". Frontiers in Neuroscience. doi:10.3389/fnins.2013.00089.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1]

[2]