ULBP3

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ULBP3
Protein ULBP3 PDB 1kcg.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ULBP3, RAET1N, N2DL-3, NKG2DL3, UL16 binding protein 3
External IDs HomoloGene: 129737 GeneCards: ULBP3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024518

n/a

RefSeq (protein)

NP_078794

n/a

Location (UCSC) Chr 6: 150.06 – 150.07 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

UL16 binding protein 3 (ULBP3) is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6.[2][3] ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus.[2][3] The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.[2][3] It functions as a stress-induced ligand for NKG2D receptor.[2]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ a b c d Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445. 
  3. ^ a b c Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464. 

Further reading[edit]