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Archaeological significance

Dental calculus has been shown to contain well preserved DNA and protein in archaeological samples.^[1] The information these molecules contain can reveal information about the oral microbiome of the host and the presence of pathogens.^[2] It is also possible to identify dietary sources^[3] as well as study dietary shifts.^[4]

^ Metcalf, J. L.; Ursell, L. K.; Knight, R (2014). "Ancient human oral plaque preserves a wealth of biological data". Nature Genetics. 46 (4): 321–323. doi:10.1038/ng.2930. PMID 24675519. Retrieved 2014-11-11.
^ Warinner, Christina; Rodrigues, João F Matias; Vyas, Rounak; Trachsel, Christian; Shved, Natallia; Grossmann, Jonas; Radini, Anita; Hancock, Y; Tito, Raul Y (April 2014). "Pathogens and host immunity in the ancient human oral cavity". Nature Genetics. 46 (4): 336–344. doi:10.1038/ng.2906. ISSN 1546-1718.
^ Weyrich, Laura S.; Duchene, Sebastian; Soubrier, Julien; Arriola, Luis; Llamas, Bastien; Breen, James; Morris, Alan G.; Alt, Kurt W.; Caramelli, David (April 2017). "Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus". Nature. 544 (7650): 357–361. doi:10.1038/nature21674. ISSN 1476-4687.
^ Adler, Christina J; Dobney, Keith; Weyrich, Laura S; Kaidonis, John; Walker, Alan W; Haak, Wolfgang; Bradshaw, Corey J A; Townsend, Grant; Sołtysiak, Arkadiusz (April 2013). "Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions". Nature Genetics. 45 (4): 450–455. doi:10.1038/ng.2536. ISSN 1546-1718.

[1] Metcalf, J. L.; Ursell, L. K.; Knight, R (2014). "Ancient human oral plaque preserves a wealth of biological data". Nature Genetics. 46 (4): 321–323. doi:10.1038/ng.2930. PMID 24675519. Retrieved 2014-11-11.

[2] Warinner, Christina; Rodrigues, João F Matias; Vyas, Rounak; Trachsel, Christian; Shved, Natallia; Grossmann, Jonas; Radini, Anita; Hancock, Y; Tito, Raul Y (April 2014). "Pathogens and host immunity in the ancient human oral cavity". Nature Genetics. 46 (4): 336–344. doi:10.1038/ng.2906. ISSN 1546-1718.

[3] Weyrich, Laura S.; Duchene, Sebastian; Soubrier, Julien; Arriola, Luis; Llamas, Bastien; Breen, James; Morris, Alan G.; Alt, Kurt W.; Caramelli, David (April 2017). "Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus". Nature. 544 (7650): 357–361. doi:10.1038/nature21674. ISSN 1476-4687.

[4] Adler, Christina J; Dobney, Keith; Weyrich, Laura S; Kaidonis, John; Walker, Alan W; Haak, Wolfgang; Bradshaw, Corey J A; Townsend, Grant; Sołtysiak, Arkadiusz (April 2013). "Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions". Nature Genetics. 45 (4): 450–455. doi:10.1038/ng.2536. ISSN 1546-1718.

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