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Aberrant methylation also occurs as a consequence of aging.[1] However, half of the genes that show age-related methylation are the exact genes involved in colorectal cancer.[2] These findings may suggest a reason for age being associated with the increased risk of developing colorectal cancer.[citation needed]

Epigenetic alterations involved in the development of colorectal cancer may affect patients' response to chemotherapy. [3]

  1. ^ Lao, Victoria Valinluck; Grady, William M. (2011-10-18). "Epigenetics and Colorectal Cancer". Nature reviews. Gastroenterology & hepatology. 8 (12): 686–700. doi:10.1038/nrgastro.2011.173. ISSN 1759-5045. PMC 3391545. PMID 22009203.{{cite journal}}: CS1 maint: PMC format (link)
  2. ^ Lao, Victoria Valinluck; Grady, William M. (2011-10-18). "Epigenetics and Colorectal Cancer". Nature reviews. Gastroenterology & hepatology. 8 (12): 686–700. doi:10.1038/nrgastro.2011.173. ISSN 1759-5045. PMC 3391545. PMID 22009203.{{cite journal}}: CS1 maint: PMC format (link)
  3. ^ Coppedè, Fabio; Lopomo, Angela; Spisni, Roberto; Migliore, Lucia (2014-01-28). "Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer". World Journal of Gastroenterology : WJG. 20 (4): 943–956. doi:10.3748/wjg.v20.i4.943. ISSN 1007-9327. PMC 3921546. PMID 24574767.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

Comments

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Thanks for sharing your suggestions. I added a citation needed tag to one of your sentences above. I also fixed one spacing error with your reference. In general your formatting looks great. Can you add some wikilinks to methylation, aberrant etc? Is there a way to present this more in lay terminology so someone without a background in medical science can understand? Great work so far! JenOttawa (talk) 01:58, 7 November 2018 (UTC)