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KIAA0895 is a human gene that codes for a protein known as KIAA0895 protein or hypothetical protein LOC23366.[1] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.[2]

Gene

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The KIAA0895 gene is located at p14.2 on chromosome 7.

The location of the KIAA0895 gene on chromosome 7

It can be transcribed into 15 different transcript variants, which in turn can produce 13 different isoforms of the protein.[3]

The genomic DNA is 65,976 [base pair]s long [1], while the longest mRNA that it produces is 4463 bases long.

Gene Neighborhood

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KIAA0895 is surrounded by the following genes on chromosome 7 [1]:

Protein

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The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long[4].

Regions

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Domain of unknown function 1704
Identifiers
SymbolDUF1704
PfamPF08014
InterProIPR012548
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

LOC23366 contains a domain of unknown function called DUF 1704 [5].

It also contains a region of low complexity from position 120 to position 150 in the protein[6], and an arginine-rich area from position 12 to position 51[7].

Post-translational Modification

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The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout it's structure, particularly in the first half of the protein[8] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites[9].

The predicted serine, threonine, and tyrosine phosphorylation sites of the KIAA0895 protein

Expression

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KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.[10]. It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.

Conservation

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KIAA0895 has one paralog in humans known as KIAA0895L [11]. Orthologs have been found in all mammals, and eukaryotes through T. thermophila[12]. The full list of organisms in which orthologs have been found is given below.

References

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  1. ^ a b c "Entrez Gene: KIAA0895". Retrieved 4-24-2011. {{cite web}}: Check date values in: |accessdate= (help)
  2. ^ "GeneCards: KIAA0895 Gene". Retrieved 4-24-2011. {{cite web}}: Check date values in: |accessdate= (help)
  3. ^ "NCBI AceView: KIAA0895". Retrieved 4-24-2011. {{cite web}}: Check date values in: |accessdate= (help)
  4. ^ "NCBI Protein: LOC23366 isoform 1". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  5. ^ "Wellcome Trust Sanger Institute, Pfam". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  6. ^ "MyHits Dotlet". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  7. ^ "Uniprot". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  8. ^ "DTU Center for Biological Sciences, NetPhos". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  9. ^ "DTU Center for Biological Sciences, NetNGlyc". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  10. ^ "NCBI Unigene EST Profile: KIAA0895". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  11. ^ "KEGG: KIAA0895". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)
  12. ^ "NCBI BLAST". Retrieved 5-9-2011. {{cite web}}: Check date values in: |accessdate= (help)

Category:Human proteins