User:Mr. Ibrahem/Alosetron

Mr. Ibrahem/Alosetron
Clinical data
Pronunciation	al oh’ se tron
Trade names	Lotronex
AHFS/Drugs.com	Monograph
MedlinePlus	a601230
Routes of; administration	By mouth (tablets)
Drug class	5-HT3 receptor blocker
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	50–60%
Protein binding	82%
Metabolism	Liver (including CYP2C9, CYP3A4 and CYP1A2)
Elimination half-life	1.5–1.7 hours
Excretion	Renal 73%, faecal 24%
Identifiers
	IUPAC name 5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one;
Chemical and physical data
Formula	C17H18N4O
Molar mass	294.358 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1nc[nH]c1CN2CCc4c(C2=O)c3ccccc3n4C;
	InChI InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19) ; Key:JSWZEAMFRNKZNL-UHFFFAOYSA-N ;
	(verify)

Alosetron, sold under the brand name Lotronex among others, is a medication used for diarrhea-predominant irritable bowel syndrome (IBS) in women.^[1] It should only be used in those with severe disease who cannot be managed with other treatments.^[3] It is taken by mouth.^[3]

Common side effects include constipation, abdominal pain, and nausea.^[2] Other side effects may include bowel obstruction and ischemic colitis.^[2] Safety in pregnancy is unclear.^[2] It is a 5-HT₃ receptor blocker.^[1]

Alosetron was patented in 1987 and came into medical use in the 1990s.^[4]^[1] It was temporarily withdrawn in 2000 due to isssues with constipation but was reintroduced in 2002.^[1] It is available as a generic medication.^[5] In the United States a month costs about 240 USD as of 2022.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 14 January 2022.
^ ^a ^b ^c ^d "DailyMed - ALOSETRON HYDROCHLORIDE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 April 2021. Retrieved 14 January 2022.
^ ^a ^b "Alosetron Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 14 January 2022.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2021-10-11.
^ ^a ^b "Alosetron Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 January 2016. Retrieved 14 January 2022.

[Liv2022-1] ^ ^a ^b ^c ^d ^e ^f "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 14 January 2022.

[PI2022-2] "DailyMed - ALOSETRON HYDROCHLORIDE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 April 2021. Retrieved 14 January 2022.

[AHFS2022-3] "Alosetron Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 14 January 2022.

[4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2021-10-11.

[GX2022-5] "Alosetron Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 January 2016. Retrieved 14 January 2022.

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