User:Mr. Ibrahem/Benzatropine

From Wikipedia, the free encyclopedia
Mr. Ibrahem/Benzatropine
Clinical data
Trade namesCogentin, others
Other namesBenztropine, benztropine (BAN UK), benztropine (USAN US)
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth, IM, IV
Drug classAnticholinergic[1]
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Elimination half-life12-24 hours
ExcretionUrine
Identifiers
  • (3-endo)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
Chemical and physical data
FormulaC21H25NO
Molar mass307.437 g·mol−1
3D model (JSmol)
  • CN4[C@@H]1CC[C@H]4C[C@H](C1)OC(c2ccccc2)c3ccccc3
  • InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+ checkY
  • Key:GIJXKZJWITVLHI-PMOLBWCYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benzatropine, also spelled benztropine, is a medication used to treat a type of movement disorder due to antipsychotics known as dystonia and parkinsonism.[1] It is not useful for tardive dyskinesia.[1] It is taken by mouth or by injection into a vein or muscle.[1] Benefits are seen within two hours and last for up to ten hours.[3][4]

Common side effects include dry mouth, blurry vision, nausea, and constipation.[1] Serious side effect may include urinary retention, hallucinations, hyperthermia, and poor coordination.[1] It is unclear if use during pregnancy or breastfeeding is safe.[5] Benzatropine is an anticholinergic which works by blocking the activity of the muscarinic acetylcholine receptor.[1]

Benzatropine was approved for medical use in the United States in 1954.[1] It is available as a generic medication.[1] In the United States the wholesale cost is about US$6 per month.[6] In 2017, it was the 226th most commonly prescribed medication in the United States, with more than two million prescriptions.[7][8] It is sold under the brand name Cogentin among others.[1]

References[edit]

  1. ^ a b c d e f g h i j k l "Benztropine Mesylate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 June 2019. Retrieved 9 April 2019.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 7 September 2020.
  3. ^ Pagliaro, Louis A.; Pagliaro, Ann M. (1999). PNDR, Psychologists' Neuropsychotropic Drug Reference. Psychology Press. p. 47. ISBN 9780876309568. Archived from the original on 2020-07-26. Retrieved 2019-04-09.
  4. ^ Aschenbrenner, Diane S.; Venable, Samantha J. (2009). Drug Therapy in Nursing. Lippincott Williams & Wilkins. p. 197. ISBN 9780781765879. Archived from the original on 2020-07-26. Retrieved 2019-04-09.
  5. ^ "Benztropine (Cogentin) Use During Pregnancy". Drugs.com. Archived from the original on 6 June 2019. Retrieved 9 April 2019.
  6. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  7. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  8. ^ "Benztropine Mesylate - Drug Usage Statistics". ClinCalc. Archived from the original on 3 July 2020. Retrieved 11 April 2020.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Benzatropine&oldid=1112715712"