User:Mr. Ibrahem/Brinzolamide
Appearance
Clinical data | |
---|---|
Pronunciation | brin ZOH la mide |
Trade names | Azopt, Befardin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601233 |
License data |
|
Pregnancy category |
|
Routes of administration | Eye drop |
Drug class | Carbonic anhydrase inhibitor[2] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | Absorbed systemically, but below detectable levels (less than 10 ng/mL) |
Protein binding | ~60% |
Elimination half-life | 111 days |
Excretion | Kidney (60%) |
Identifiers | |
| |
Chemical and physical data | |
Formula | C12H21N3O5S3 |
Molar mass | 383.50 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Brinzolamide, sold under the brand name Azopt among others, is a medication used to treat glaucoma, specifically open-angle glaucoma.[2] It is often used together with beta blockers or prostaglandin analogues.[3] It is used as an eye drop.[2]
Common side effects include a bitter taste in the mouth and temporary blurry vision.[3] Safety in pregnancy is unclear.[4] It is a carbonic anhydrase inhibitor, which decreases the production of aqueous humour.[2][3]
Brinzolamide was approved for medical use in the United States in 1998 and Europe in 2000.[2][3] Generic versions were approved in 2020.[5] In the United Kingdom 5 ml costs the NHS about £3 as of 2021.[6] This amount in the United States is about 47 USD.[7]
References[edit]
- ^ "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Archived from the original on 28 November 2020. Retrieved 17 August 2020.
- ^ a b c d e f "Brinzolamide Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 11 January 2022.
- ^ a b c d e "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.
- ^ "Brinzolamide". Archived from the original on 19 April 2021. Retrieved 11 January 2022.
- ^ Research, Center for Drug Evaluation and (23 February 2021). "2020 First Generic Drug Approvals". FDA. Archived from the original on 26 September 2021. Retrieved 11 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1226. ISBN 978-0857114105.
- ^ "Brinzolamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 2 October 2016. Retrieved 11 January 2022.