User:Mr. Ibrahem/Bromocriptine

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Mr. Ibrahem/Bromocriptine
Clinical data
Trade namesParlodel, Cycloset, others[1]
Other namesBromocriptine mesilate, bromocriptine mesylate, 2-Bromoergocriptine; CB-154
AHFS/Drugs.comMonograph
MedlinePlusa682079
Pregnancy
category
  • AU: A
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability28% of oral dose
MetabolismExtensively liver-mediated
Elimination half-life12–14 hours
Excretion85% bile (feces), 2.5–5.5% urine
Identifiers
  • (5′α)-2-Bromo-12′-hydroxy-5′-(2-methylpropyl)-3′,6′,18-trioxo-2′-(propan-2-yl)ergotaman
Chemical and physical data
FormulaC32H40BrN5O5
Molar mass654.606 g·mol−1
3D model (JSmol)
  • BrC1=C(C[C@H]2N(C)C3)C4=C(C=CC=C4C2=C[C@H]3C(N[C@]5(C(C)C)O[C@@]6(N([C@@H](CC(C)C)C(N7CCC[C@H]76)=O)C5=O)O)=O)N1
  • InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1 checkY
  • Key:OZVBMTJYIDMWIL-AYFBDAFISA-N checkY
  (verify)

Bromocriptine, sold under the brand name Parlodel among others, is a medication used to treat prolactinomas, Parkinson's disease, acromegaly, neuroleptic malignant syndrome, and stop milk production.[2][3] It may also be used in type 2 diabetes.[4] It is taken by mouth.[2]

Common side effects include nausea, headache, tiredness, dizziness, constipation, and sleepiness.[3] Other side effects may include low blood pressure, and pericardial effusions, confusion.[3] It has been used by many pregnant women without any evidence of harm to the baby.[5] It works by activating dopamine receptors and decreasing the release of prolactin.[2]

Bromocriptine was patented in 1968 and approved for medical use in 1975.[6] It is available as a generic medication.[2] In the United Kingdom 30 pills of 2.5 mg cost the NHS about £75 as of 2021.[2] In the United States this amount costs about 30 USD.[7]

References[edit]

  1. ^ "Bromocriptine international brand names". Drugs.com. Archived from the original on 6 August 2017. Retrieved 13 July 2017.
  2. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.
  3. ^ a b c d e "Bromocriptine Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 12 January 2022.
  4. ^ a b "DailyMed - CYCLOSET- bromocriptine mesylate tablet". dailymed.nlm.nih.gov. Archived from the original on 29 March 2021. Retrieved 12 January 2022.
  5. ^ "Bromocriptine Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 12 January 2022.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 533. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-06-30.
  7. ^ "Bromocriptine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 12 January 2022.
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