User:Mr. Ibrahem/Cabergoline

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Mr. Ibrahem/Cabergoline
Clinical data
Trade namesCabaser, Dostinex, others
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
Drug classDopamine receptor agonists
Legal status
Legal status
Pharmacokinetic data
BioavailabilityFirst-pass effect seen; absolute bioavailability unknown
Protein bindingModerately bound (40–42%); concentration-independent
MetabolismLiver, predominately via hydrolysis of the acylurea bond or the urea moiety
Elimination half-life63–69 hours (estimated)
ExcretionUrine (22%), feces (60%)
Identifiers
  • (6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Chemical and physical data
FormulaC26H37N5O2
Molar mass451.615 g·mol−1
3D model (JSmol)
  • [H][C@]12C[C@@H](C(=O)N(CCCN(C)C)C(=O)NCC)CN(CC=C)[C@]1([H])Cc3c[nH]c4cccc2c34
  • InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1 checkY
  • Key:KORNTPPJEAJQIU-KJXAQDMKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cabergoline, sold under the brand names Dostinex among others, is a medication used for high blood prolactin and less commonly for Parkinson's and to suppress milk production.[1][2] Outside of pregnancy, it is preferred to bromocriptine due to less side effects.[1] It is taken by mouth.[1]

Common side effects include nausea, abdominal pain, headache, sleepiness, and constipation.[1] Other side effects include pulmonary fibrosis and low blood pressure with standing.[1] There is no clear evidence of harm of use during pregnancy, but such use has not been well studied.[5] Carbergoline works by stimulating dopamine receptors and decreasing the release of prolactin.[2]

Cabergoline was patented in 1980 and approved for medical use in 1993.[6] It is avaliable as a generic medication.[2] In the United Kingdom 20 tablets of 1 mg costs the NHS about 65 pounds in 2020.[2] This amount in the US costs about 72 USD.[7]

References[edit]

  1. ^ a b c d e f g "Cabergoline Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 9 November 2020.
  2. ^ a b c d e BNF 79. London: Pharmaceutical Press. March 2020. p. 432. ISBN 978-0857113658.
  3. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 30 October 2020. Retrieved 9 November 2020.
  4. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 11 April 2021. Retrieved 9 November 2020.
  5. ^ "Cabergoline (Dostinex) Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 9 November 2020.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 533. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2020-09-19.
  7. ^ "Cabergoline Prices and Cabergoline Coupons". GoodRx. Retrieved 9 November 2020.
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