User:Mr. Ibrahem/Calcitriol

From Wikipedia, the free encyclopedia
Mr. Ibrahem/Calcitriol
Clinical data
PronunciationUS: /ˌkælsɪˈtraɪɒl/;[1][2][3][4][5]
UK: /kælˈsɪtriɒl/
Trade namesRocaltrol, Calcijex, Decostriol, others
Other names1,25-dihydroxycholecalciferol, 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1α,25-(OH)2D3, 1,25(OH)2D[6]
AHFS/Drugs.comMonograph
MedlinePlusa682335
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, IV[7]
Legal status
Legal status
Pharmacokinetic data
Protein binding99.9%
MetabolismKidney
Elimination half-life5–8 hours (adults), 27 hours (children)
ExcretionFaeces (50%), urine (16%)
Identifiers
  • (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
Chemical and physical data
FormulaC27H44O3
Molar mass416.646 g·mol−1
3D model (JSmol)
  • C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
  • InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 checkY
  • Key:GMRQFYUYWCNGIN-NKMMMXOESA-N checkY
  (verify)

Calcitriol is the active form of vitamin D, normally made in the kidney.[10] A manufactured form is used to treat kidney disease with low blood calcium, hyperparathyroidism due to kidney disease, low blood calcium due to hypoparathyroidism, osteoporosis, osteomalacia, and familial hypophosphatemia.[7][8] It is taken by mouth or by injection into a vein.[7]

Excessive amount commonly results in weakness, headache, nausea, constipation, urinary tract infections, and abdominal pain.[7][8] Serious side effects may include high blood calcium and anaphylaxis.[7] Regular blood tests are recommended after the medication is started and when the dose is changed.[8] Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines.[7]

Calcitriol was approved for medical use in the United States in 1978.[7] It is available as a generic medication.[8] A month supply in the United Kingdom costs the NHS about 9.70 £ as of 2019.[8] In the United States the wholesale cost of this amount is about US$27.[11] In 2017, it was the 256th most commonly prescribed medication in the United States, with more than one million prescriptions.[12][13]

References[edit]

  1. ^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.
  2. ^ Wolters Kluwer, Stedman's Medical Dictionary, Wolters Kluwer.
  3. ^ Merriam-Webster, Merriam-Webster's Medical Dictionary, Merriam-Webster.
  4. ^ Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt, archived from the original on 2015-09-25, retrieved 2015-09-25.
  5. ^ Merriam-Webster, Merriam-Webster's Unabridged Dictionary, Merriam-Webster.
  6. ^ "IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D. Recommendations 1981". European Journal of Biochemistry. 124 (2): 223–7. May 1982. doi:10.1111/j.1432-1033.1982.tb06581.x. PMID 7094913.
  7. ^ a b c d e f g h i "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April 2019.
  8. ^ a b c d e f g British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.
  9. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 9 September 2020.
  10. ^ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006.
  11. ^ "CY 2016 Outlier Services" (PDF). Retrieved 13 April 2019.
  12. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  13. ^ "Calcitriol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Calcitriol&oldid=1071015332"