User:Mr. Ibrahem/Cefdinir

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Mr. Ibrahem/Cefdinir
Clinical data
PronunciationSEF-di-nir
Trade namesCefzon, Omnicef, others
AHFS/Drugs.comMonograph
MedlinePlusa698001
License data
Routes of
administration		By mouth
Drug classThird-generation cephalosporin[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability16% to 21% (dose-dependent)
Protein binding60% to 70%
MetabolismNegligible
Elimination half-life1.7 ± 0.6 hours
ExcretionKidney
Identifiers
  • 8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-
    ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-
    azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Chemical and physical data
FormulaC14H13N5O5S2
Molar mass395.41 g·mol−1
3D model (JSmol)
  • O=C2N1/C(=C(/C=C)CS[C@@H]1[C@@H]2NC(=O)C(=N\O)/c3nc(sc3)N)C(=O)O
  • InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1 checkY
  • Key:RTXOFQZKPXMALH-GHXIOONMSA-N checkY
  (verify)

Cefdinir, sold under the brand name Omnicef among others, is an antibiotic used to treat pneumonia, otitis media, strep throat, and cellulitis.[1] It is a less preferred option for pneumonia, otitis media, and strep throat which may be used in those with a severe allergy to penicillin.[1] It is taken by mouth.[1]

Common side effects include diarrhea, nausea, and a skin rash.[1] Serious side effects may include Clostridioides difficile infection, anaphylaxis, and Stevens–Johnson syndrome.[1] Use in pregnancy and breastfeeding is believed to be safe but has not been well studied.[3] It is a third-generation cephalosporin and works by interfering with a bacteria's ability to make a cell wall resulting in its death.[1]

It was patented in 1979 and approved for medical use in 1991.[4] It is available as a generic medication.[1] In the United States the wholesale cost of ten days of medication is about US$9.40.[5] In 2017, it was the 198th most commonly prescribed medication in the United States, with more than two million prescriptions.[6][7]

References[edit]

  1. ^ a b c d e f g h i j "Cefdinir Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 August 2019. Retrieved 23 March 2019.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 18 September 2020. Retrieved 9 September 2020.
  3. ^ "Cefdinir Use During Pregnancy". Drugs.com. Archived from the original on 23 March 2019. Retrieved 3 March 2019.
  4. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 49X. ISBN 9783527607495. Archived from the original on 2019-03-06. Retrieved 2019-03-02.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  7. ^ "Cefdinir - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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