User:Mr. Ibrahem/Clorazepate

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Mr. Ibrahem/Clorazepate
Clinical data
Pronunciationklor az' e pate[1]
Trade namesTranxene, Tranxilium, Novo-Clopate, others
Other namesClorazepate dipotassium
AHFS/Drugs.comMonograph
MedlinePlusa682052
Routes of
administration		By mouth
Drug classBenzodiazepine[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability91%
MetabolismLiver
Onset of action~ 1 hr[2]
Elimination half-life48 hours
Duration of actionUp to 3 days[3]
ExcretionKidney
Identifiers
  • 7-Chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
Chemical and physical data
FormulaC16H11ClN2O3
Molar mass314.73 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O
  • InChI=1S/C16H11ClN2O3/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12/h1-8,14H,(H,18,20)(H,21,22) checkY
  • Key:XDDJGVMJFWAHJX-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Clorazepate, sold under the brand name Tranxene among others, is a medication used to treat alcohol withdrawal, anxiety, and seizures.[4] It is taken by mouth.[4] Onset of effects is about an hour and these can last 1 to 3 days.[2][3]

Common side effects include drowsiness, poor coordination, trouble talking, and dizziness.[1] Other side effects may include abuse and withdrawal symptoms after prolonged use.[4] Use during early pregnancy may harm the baby.[4] It may interact with opioids.[4] It is a benzodiazepine and works by enhancing gamma-aminobutyric acid (GABA).[1]

Clorazepate was patented in 1965 and approved for medical use in 1967.[5] It is available as a generic medication.[6] In the United States 30 pills of 7.5 mg costs about 30 USD as of 2022.[6] In the United States it is a schedule IV controlled substance.[4]

References[edit]

  1. ^ a b c d e "Clorazepate". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 5 January 2022.
  2. ^ a b Mauk, Kristen L. (14 April 2017). Gerontological Nursing Competencies for Care. Jones & Bartlett Learning. p. 499. ISBN 978-1-284-10447-9. Archived from the original on 11 January 2022. Retrieved 5 January 2022.
  3. ^ a b Clark, Michelle A.; Harvey, Richard A.; Finkel, Richard; Rey, Jose A.; Whalen, Karen (15 December 2011). Pharmacology. Lippincott Williams & Wilkins. p. 114. ISBN 978-1-4511-1314-3. Archived from the original on 11 January 2022. Retrieved 5 January 2022.
  4. ^ a b c d e f g Cite error: The named reference AHFS2022 was invoked but never defined (see the help page).
  5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-07-24.
  6. ^ a b "Clorazepate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 5 January 2022.
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