User:Mr. Ibrahem/Dicycloverine

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Mr. Ibrahem/Dicycloverine
Clinical data
Trade namesByclomine, Bentyl, Dibent, others
AHFS/Drugs.comMonograph
MedlinePlusa684007
License data
Pregnancy
category
  • AU: B1
Legal status
Legal status
Pharmacokinetic data
Protein binding>99%
Elimination half-life5 h
Identifiers
  • 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Chemical and physical data
FormulaC19H35NO2
Molar mass309.494 g·mol−1
3D model (JSmol)
  • O=C(OCCN(CC)CC)C1(CCCCC1)C2CCCCC2
  • InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 checkY
  • Key:CURUTKGFNZGFSE-UHFFFAOYSA-N checkY
  (verify)

Dicycloverine, also known as dicyclomine, is a medication that is used to treat spasms of the intestines such as occur in irritable bowel syndrome.[2][3] It is taken by mouth or by injection into a muscle.[3] While it has been used in baby colic and enterocolitis, evidence does not support these uses.[3]

Common side effects include dry mouth, blurry vision, weakness, sleepiness, and lightheadedness.[3] Serious side effects may include psychosis and breathing problems in babies.[3] Use in pregnancy appears to be safe while use during breastfeeding is not recommended.[4] How it works is not entirely clear.[3]

Dicycloverine was approved for medical use in the United States in 1950.[3] It is available as a generic medication.[2] In the United Kingdom the NHS pays about 1.84 £ per dose as of 2019.[2] In the United States the wholesale cost of this amount is about US$0.15.[5] In 2017, it was the 181st most commonly prescribed medication in the United States, with more than three million prescriptions.[6][7]

References[edit]

  1. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 7 September 2020.
  2. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 759. ISBN 9780857113382.
  3. ^ a b c d e f g "Dicyclomine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 5 May 2019. Retrieved 3 March 2019.
  4. ^ "Dicyclomine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  7. ^ "Dicyclomine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 12 July 2020. Retrieved 11 April 2020.
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