User:Mr. Ibrahem/Dofetilide
Clinical data | |
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Trade names | Tikosyn |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601235 |
Drug class | Class III antiarrhythmic agent[1] |
Pharmacokinetic data | |
Bioavailability | 96% (by mouth) |
Protein binding | 60% -70% |
Elimination half-life | 10 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C19H27N3O5S2 |
Molar mass | 441.56 g·mol−1 |
3D model (JSmol) | |
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Dofetilide, sold under the brand name Tikosyn, is a medication used to keep people with atrial fibrillation or atrial flutter in sinus rhythm.[1] It is only indicated in those who have been in an abnormal rhythm for more than a week and have significant symptoms.[2] It is taken by mouth.[1]
Common side effects include headache, chest pain, and dizziness.[1] Other side effects may include QT prolongation and potentially an increased risk of death.[1] It should not be used in people with severe kidney problems.[1] Safety in pregnancy is unclear.[1] It is a class III antiarrhythmic agent.[1]
Dofetilide was approved for medical use in the United States in 1999.[1] While it was approved in Europe in 1999, this was withdrawn in 2004.[3] In the United States it costs about 25 USD per month.[4]
References[edit]
- ^ a b c d e f g h i j k "Dofetilide Monograph for Professionals". Drugs.com. Archived from the original on 10 August 2020. Retrieved 26 December 2021.
- ^ "DailyMed - DOFETILIDE capsule". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 26 December 2021.
- ^ "Tikosyn". Archived from the original on 11 January 2022. Retrieved 26 December 2021.
- ^ "Dofetilide Prices and Dofetilide Coupons - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 26 December 2021.