User:Mr. Ibrahem/Etodolac

Mr. Ibrahem/Etodolac
Clinical data
Trade names	Etolyn, Etopan, Lodine, others
AHFS/Drugs.com	Monograph
MedlinePlus	a692015
Pregnancy; category	C;
Routes of; administration	By mouth
Drug class	Nonsteroidal anti-inflammatory drug (NSAID)
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	100%
Metabolism	liver
Elimination half-life	7.3 ± 4.0 hours
Excretion	renal
Identifiers
	IUPAC name (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid;
Chemical and physical data
Formula	C17H21NO3
Molar mass	287.359 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	145 to 148 °C (293 to 298 °F)
Solubility in water	3.92e-02 mg/mL [ALOGPS] mg/mL (20 °C)
	SMILES CCc2cccc3c1CCOC(CC)(CC(=O)O)c1[nH]c23;
	InChI InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) ; Key:NNYBQONXHNTVIJ-UHFFFAOYSA-N ;
	(verify)

Etodolac, sold under the brand name Etolyn among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation.^[2] This may include in conditions such as osteoarthritis or rheumatic arthritis.^[2] It is taken by mouth.^[2]

Common side effects include heart burn, abdominal pain, GI bleeding, nausea, kidney problems, dizziness, swelling, bleeding, ringing in the ears, and liver problems.^[1] Other side effects may include heart attacks, high blood pressure, heart failure, and anaphylaxis.^[1] Use in the later half of pregnancy may harm the baby.^[1] It works by blocking COX1 and COX2.^[1]

Etodolac was patented in 1971 and approved for medical use in 1985.^[3] It was approved in the U.S. in 1991.^[1] It is available as a generic medication.^[4] In the United Kingdom 30 tablets of 600 mg costs the NHS about £15 as of 2021.^[2] This amount in the United States costs about 22 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g "Etodolac Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2021. Retrieved 16 December 2021.
^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1184. ISBN 978-0857114105.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. Archived from the original on 2021-07-26. Retrieved 2020-12-29.
^ ^a ^b "Etodolac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g "Etodolac Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2021. Retrieved 16 December 2021.

[BNF81-2] ^ ^a ^b ^c ^d ^e ^f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1184. ISBN 978-0857114105.

[Fis2006-3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. Archived from the original on 2021-07-26. Retrieved 2020-12-29.

[GX2021-4] "Etodolac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.

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