User:Mr. Ibrahem/Exemestane
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| Clinical data | |
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| Pronunciation | /ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn |
| Trade names | Aromasin |
| Other names | FCE-24304 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a607006 |
| Routes of administration | By mouth |
| Drug class | Aromatase inhibitor; Antiestrogen |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | ~60%[citation needed] |
| Protein binding | 90% |
| Metabolism | Liver (CYP3A4, aldo-keto reductase) |
| Elimination half-life | 24 hours |
| Duration of action | 4–5 days[citation needed] |
| Excretion | Urine and feces ~ 1:1 (mainly metabolites) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C20H24O2 |
| Molar mass | 296.410 g·mol−1 |
| 3D model (JSmol) | |
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Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer.[2] Specifically it is used for early estrogen receptor positive disease or advanced disease that has become resistant to tamoxifen.[3] It is taken by mouth.[2]
Common side effects include hot flushes, tiredness, joint pain, trouble sleeping, and increased sweating.[3] Other side effects may include osteoporosis.[3] Use in pregnancy may harm the baby.[3] It is a aromatase inhibitor which blocks the creation of estrogen.[3][4]
Exemestane was approved for medical use in the United Kingdom in 1998 and the United States in 1999.[5][6] It is available as a generic medication.[2] In the United Kingdom a month costs the NHS about £21.[2] This amount in the United States costs about 50 USD.[7]
References[edit]
- ^ Exemestane Archived 2015-12-23 at the Wayback Machine at ChEBI
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 998. ISBN 978-0857114105.
- ^ a b c d e f "DailyMed - EXEMESTANE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 17 December 2021.
- ^ "Exemestane". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 December 2021.
- ^ "Aromasin - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 13 May 2021. Retrieved 17 December 2021.
- ^ "Exemestane Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 17 December 2021.
- ^ "Exemestane Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 21 October 2016. Retrieved 17 December 2021.