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User:Mr. Ibrahem/Famciclovir

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Mr. Ibrahem/Famciclovir
Clinical data
Pronunciation/ˌfæmˈsaɪkloʊˌvɪər/[1]
Trade namesFamvir, others
AHFS/Drugs.comMonograph
MedlinePlusa694038
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth
Drug classAntiviral
Legal status
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability75–77%
Protein binding20–25%
MetabolismLiver, circulation, intestinal wall (to penciclovir)
Elimination half-life2–2.3 hours
ExcretionKidney, faecal
Identifiers
  • 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
Chemical and physical data
FormulaC14H19N5O4
Molar mass321.337 g·mol−1
3D model (JSmol)
Melting point103 °C (217 °F)
  • O=C(OCC(COC(=O)C)CCn1c2nc(ncc2nc1)N)C
  • InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) checkY
  • Key:GGXKWVWZWMLJEH-UHFFFAOYSA-N checkY
  (verify)

Famciclovir, sold under the brand name Famvir among others, is an antiviral used to treat herpes zoster (shingles) and herpes simplex.[2] It is used for genital herpes as well as cold sores and may be used to treat active outbreaks and to prevent outbreaks.[3] It is taken by mouth.[3]

Common side effects include headache, nausea, and diarrhea.[3] Lower doses may be used in people with kidney problems.[3] While there is no evidence of harm in pregnancy, such use has not been well studied.[4] It is a prodrug of penciclovir.[2] This results in a guanosine analogue which blocks viral DNA polymerase.[2]

Famciclovir was patented in 1983 and approved for medical use in 1994.[5][6] It is available as a generic medication.[7] In the United Kingdom 14 tablets of 500 mg costs the NHS about £280 as of 2021.[7] This amount in the United States is about 16 USD.[8]

References[edit]

  1. ^ "Famciclovir". Merriam-Webster.com Dictionary. Retrieved 2016-01-22.
  2. ^ a b c d "Famciclovir". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 10 December 2021.
  3. ^ a b c d e "Famciclovir Monograph for Professionals". Drugs.com. Archived from the original on 16 November 2021. Retrieved 10 December 2021.
  4. ^ "Famciclovir (Famvir) Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 10 December 2021.
  5. ^ Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-12-06.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2020-12-06.
  7. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 675. ISBN 978-0857114105.
  8. ^ "Famciclovir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 December 2021.
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