User:Mr. Ibrahem/Ipilimumab
 | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | CTLA-4 |
| Clinical data | |
| Pronunciation | i pi lim′ ue mab |
| Trade names | Yervoy |
| Other names | BMS-734016,[1] MDX-010,[2] MDX-101 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a611023 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Intravenous (IV) |
| Legal status | |
| Legal status | |
| Chemical and physical data | |
| Formula | C6742H9972N1732O2004S40 |
| Molar mass | 148634.46 g·mol−1 |
  (what is this?) (verify) | |
Ipilimumab, sold under the brand name Yervoy, is a medication used to treat melanoma, renal cell cancer, mesothelioma, and non-small cell lung cancer (NSCLC).[6][7] It is often used together with nivolumab.[7] It is given by gradual injection into a vein.[7]
Common side effects include rash, itchiness, tiredness, diarrhea, nausea, fever, thyroid problems, shortness of breath, liver inflammation, and abdominal pain.[7] Other side effects may include intestinal inflammation, toxic epidermal necrolysis, and neuropathy.[6] It is a monoclonal antibody that attaches to and blocks CTLA-4 which increases T cell activity against cancer.[7]
Ipilimumab was approved for medical use in the United States and Europe in 2011.[7][6] In the United Kingdom it costs about £15,000 for 200 mg as of 2021.[8] In the United States this amount costs about 32,300 USD.[9]
References[edit]
- ^ "Yervoy, ipilimumab (BMS-734016) - Product Profile - BioCentury". BioCentury Online Intelligence. BioCentury Publications. Archived from the original on 12 August 2016. Retrieved 11 August 2016.
- ^ USAN. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab" (Press release). American Medical Association (AMA). Archived from the original on 2016-02-23. Retrieved 2013-01-12.
- ^ "Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 3 August 2020. Archived from the original on 22 January 2021. Retrieved 2 October 2020.
- ^ "Yervoy- ipilimumab injection". DailyMed. 13 August 2020. Archived from the original on 4 August 2020. Retrieved 2 October 2020.
- ^ "Yervoy EPAR". European Medicines Agency (EMA). Archived from the original on 28 September 2020. Retrieved 2 October 2020.
- ^ a b c d "Ipilimumab Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 28 November 2021.
- ^ a b c d e f g h "Yervoy". Archived from the original on 28 September 2020. Retrieved 28 November 2021.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 918. ISBN 978-0857114105.
- ^ "Yervoy Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 January 2021. Retrieved 28 November 2021.