User:Mr. Ibrahem/Lacosamide

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Mr. Ibrahem/Lacosamide
Clinical data
Trade namesVimpat
Other names(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide
AHFS/Drugs.comMonograph
MedlinePlusa609028
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, intravenous
Drug classAnticonvulsant[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: Schedule V
  • EU: Rx-only
Pharmacokinetic data
BioavailabilityHigh
Elimination half-life13 hours
ExcretionKidney
Identifiers
  • N2-acetyl-N-benzyl-D-homoserinamide
Chemical and physical data
FormulaC13H18N2O3
Molar mass250.298 g·mol−1
3D model (JSmol)
  • O=C(N[C@@H](C(=O)NCc1ccccc1)COC)C
  • InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1 checkY
  • Key:VPPJLAIAVCUEMN-GFCCVEGCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Lacosamide, sold under the brand name Vimpat among others, is a medication used to treat epilepsy and diabetic neuropathic pain.[1][2] It is taken by mouth or injection into a vein.[1] It may be taken by itself or with other medications.[1]

Common side effects include dizziness, headache, nausea, tiredness, tremor, and diarrhea.[1] Other side effects may include syncope, arrhythmias including atrial fibrillation, poor coordination, and suicide.[1] There are concerns that use in pregnancy may harm the baby.[1] How it works is not entirely unclear, but it is beleived to affect sodium channels in the brain.[2]

Lacosamide was approved for medical use in the United States and Europe in 2008.[1][2] In the United States a dose of 100 mg twice per day costs about 1,000 USD per month as of 2021.[3] In Canada this amount costs about 200 CAD.[4] In the United Kingdom this amount costs the NHS about £95.[5]

References[edit]

  1. ^ a b c d e f g h i j "Lacosamide Monograph for Professionals". Drugs.com. Archived from the original on 10 August 2020. Retrieved 20 November 2021.
  2. ^ a b c d e "Vimpat". Archived from the original on 1 August 2021. Retrieved 20 November 2021.
  3. ^ "Vimpat Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 January 2021. Retrieved 20 November 2021.
  4. ^ "Lacosamide" (PDF). CADTH. 2011. Archived (PDF) from the original on 20 October 2020. Retrieved 20 November 2021.
  5. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 334. ISBN 978-0857114105.
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