User:Mr. Ibrahem/Lesinurad

Mr. Ibrahem/Lesinurad
Clinical data
Pronunciation	Zurampic /zəˈræmpɪk/ zə-RAM-pik
Trade names	Zurampic
AHFS/Drugs.com	Monograph
MedlinePlus	a616015
License data	EU EMA: by INN; US DailyMed: Lesinurad;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	~100%
Protein binding	>98%
Metabolism	Liver (CYP2C9)
Elimination half-life	~5 hours
Excretion	Urine (63%), feces (32%)
Identifiers
	IUPAC name 2-{[5-Bromo-4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid;
Chemical and physical data
Formula	C17H14BrN3O2S
Molar mass	404.28 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccc2c(c1)c(ccc2n3c(nnc3Br)SCC(=O)O)C4CC4;
	InChI InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23); Key:FGQFOYHRJSUHMR-UHFFFAOYSA-N;

Lesinurad, sold under the brand name Zurampic, is a medication used to treat high blood uric acid associated with gout.^[2] It is only recommended with either allopurinol or febuxostat when these medications are not sufficient.^[2] It is taken by mouth.^[2]

Common side effects include headache, kidney problems, and GERD.^[2] Other side effects may include heart problems and stroke.^[2] Safety in pregnancy is unclear.^[3] It works by blocking URAT1 and OAT4.^[2]

Lesinurad was approved for medical use in the United States in 2015.^[2] While it was approved in Europe in 2016, this approval was subsequently withdrawn.^[4] It is no longer commercially available in the United States as of 2021.^[5]

References[edit]

^ "Zurampic (lesinurad) Tablets, for Oral Use. Full Prescribing Information" (PDF). AstraZeneca AB, S-151 85 Sodertalje, Sweden. Archived from the original (PDF) on 24 December 2015. Retrieved 23 December 2015.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Lesinurad Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2020. Retrieved 21 November 2021.
^ "Lesinurad (Zurampic) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 21 November 2021.
^ "Zurampic". Archived from the original on 28 August 2021. Retrieved 21 November 2021.
^ "Zurampic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 21 November 2021.

[PI-1] "Zurampic (lesinurad) Tablets, for Oral Use. Full Prescribing Information" (PDF). AstraZeneca AB, S-151 85 Sodertalje, Sweden. Archived from the original (PDF) on 24 December 2015. Retrieved 23 December 2015.

[AHFS2021-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Lesinurad Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2020. Retrieved 21 November 2021.

[3] "Lesinurad (Zurampic) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 21 November 2021.

[EPAR2021-4] "Zurampic". Archived from the original on 28 August 2021. Retrieved 21 November 2021.

[5] "Zurampic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 21 November 2021.

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