User:Mr. Ibrahem/Midostaurin

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Mr. Ibrahem/Midostaurin
Ball-and-stick model of the midostaurin molecule
Clinical data
Trade namesRydapt, Tauritmo, others
Other namesPKC412, 4'-N-benzoylstaurosporine
AHFS/Drugs.comMonograph
Routes of
administration		By mouth
Drug classTyrosine kinase inhibitor[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Identifiers
  • (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiamzonine-1-one
Chemical and physical data
FormulaC35H30N4O4
Molar mass570.649 g·mol−1
3D model (JSmol)
  • C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
  • InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
  • Key:BMGQWWVMWDBQGC-IIFHNQTCSA-N

Midostaurin, sold under the brand name Rydapt among others, is a medication used to treat acute myeloid leukemia (AML) and systemic mastocytosis.[2] It is used in AML that has a FLT3 mutation.[1] It is taken by mouth.[2]

Common side effects include febrile neutropenia, peeling skin, vomiting, headache, and bleeding into the skin.[1] Other side effects may include anaphylaxis, pneumonitis, infertility, and prolonged QT.[2] Use in pregnancy may harm the baby.[2] It is a tyrosine kinase inhibitor that blocks KIT kinase and FLT3 tyrosine kinase.[1]

Midostaurin was approved for medical use in the United States and Europe in 2017.[2][1] In the United Kingdom 28 doses of 50 mg costs the NHS about £5,600 as of 2021.[3] This amount in the United States is about 9,900 USD.[4]

References[edit]

  1. ^ a b c d e f "Rydapt". Archived from the original on 14 November 2021. Retrieved 18 November 2021.
  2. ^ a b c d e f "Midostaurin Monograph for Professionals". Drugs.com. Archived from the original on 12 July 2021. Retrieved 18 November 2021.
  3. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1034. ISBN 978-0857114105.
  4. ^ "Rydapt Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 11 July 2021. Retrieved 18 November 2021.
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