User:Mr. Ibrahem/Nortriptyline

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Mr. Ibrahem/Nortriptyline
Skeletal formula of nortriptyline
Ball-and-stick model of the nortriptyline molecule
Clinical data
Trade namesPamelor, Noritren, Nortrilen, others
Other namesDesitriptyline; ELF-101; E.L.F. 101; N-7048
AHFS/Drugs.comMonograph
MedlinePlusa682620
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classTricyclic antidepressant (TCA)
Legal status
Legal status
Pharmacokinetic data
Bioavailability32–79[1]
Protein binding92%[1]
MetabolismLiver
Metabolites10-E-Hydroxynortriptyline
Elimination half-life18–44 hours (mean 30 hours)[1]
ExcretionUrine: 40%[1]
Feces: minor[1]
Identifiers
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Chemical and physical data
FormulaC19H21N
Molar mass263.384 g·mol−1
3D model (JSmol)
  • c3cc2c(/C(c1c(cccc1)CC2)=C/CCNC)cc3
  • InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 checkY
  • Key:PHVGLTMQBUFIQQ-UHFFFAOYSA-N checkY
  (verify)

Nortriptyline, sold under the brand name Pamelor, among others, is a medication used to treat depression, neuropathic pain, attention deficit hyperactivity disorder (ADHD), stopping smoking, and anxiety.[2][3] It does not appear to be useful for young people with depression.[3] Nortriptyline is a less preferred treatment for ADHD and stopping smoking.[3] It is taken by mouth.[3]

Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness.[3] Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues.[3] Nortriptyline may cause problems if taken during pregnancy.[3] Use during breastfeeding appears to be relatively safe.[2] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.[3]

Nortriptyline was approved for medical use in the United States in 1964.[3] It is available as a generic medication.[2] A month supply of nortriptyline at 75mg/day in the United Kingdom costs the NHS around £35.00 as of 2020.[2] In the United States the wholesale cost of this amount is about US$4.20.[5] In 2017, it was the 183rd most commonly prescribed medication in the United States, with more than three million prescriptions.[6][7]

References[edit]

  1. ^ a b c d e Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0. Archived from the original on 16 December 2019. Retrieved 15 August 2017.
  2. ^ a b c d e BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 395–396. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  3. ^ a b c d e f g h i j k "Nortriptyline Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 March 2019. Retrieved 22 March 2019.
  4. ^ a b "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 December 2020. Retrieved 7 September 2020.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  7. ^ "Nortriptyline Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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