User:Mr. Ibrahem/Orphenadrine

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Mr. Ibrahem/Orphenadrine
Clinical data
Trade namesGeneric; many brands[1]
Other namesOrphenadrine hydrochloride
AHFS/Drugs.comMonograph
MedlinePlusa682162
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, intravenous, intramuscular
Drug classAnticholinergic, antihistamine[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability90%
Protein binding95%
MetabolismLiver demethylation
Elimination half-life13-20 hours[3]
ExcretionKidney and biliary
Identifiers
  • (RS)-N,N-Dimethyl-2-[(2-methylphenyl)-phenyl-methoxy]-ethanamine
Chemical and physical data
FormulaC18H23NO
Molar mass269.388 g·mol−1
3D model (JSmol)
  • O(CCN(C)C)C(c1ccccc1)c2ccccc2C
  • InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 checkY
  • Key:QVYRGXJJSLMXQH-UHFFFAOYSA-N checkY
  (verify)

Orphenadrine, sold under many brand names, is a medication used to treat muscle pain including low back pain, and Parkinsonism.[2][4] It is taken by mouth or by injection.[2]

Common side effects include dry mouth, fast heart rate, urinary retention, blurry vision, nausea, sleepiness, and constipation.[2] Other side effects may include anaphylaxis.[2] Safety in pregnancy is unclear.[2] It is an anticholinergic and antihistamine.[2] How it works is not entirely clear.[2]

Orphenadrine was developed in the 1940s and approved for medical use in the United States in 1957.[5][2] It is available as a generic medication.[4] In the United Kingdom 30 doses of 50 mg cost the NHS about £56 as of 2021.[4] In the United States this amount costs less than 20 USD.[6]

References[edit]

  1. ^ "Orphenadrine". Drugs.com international listings. Archived from the original on 5 March 2016. Retrieved 5 February 2016.
  2. ^ a b c d e f g h i j k "Orphenadrine Monograph for Professionals". Drugs.com. Archived from the original on 11 July 2021. Retrieved 9 November 2021.
  3. ^ Labout JJ, Thijssen C, Keijser GG, Hespe W (1982). "Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man". European Journal of Clinical Pharmacology. 21 (4): 343–50. doi:10.1007/BF00637624. PMID 7056281. S2CID 24631265. Archived from the original on 2021-10-26. Retrieved 2021-10-08.
  4. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 431. ISBN 978-0857114105.
  5. ^ Deer, Timothy R.; Pope, Jason E.; Lamer, Tim J.; Provenzano, David (1 August 2019). Deer's Treatment of Pain: An Illustrated Guide for Practitioners. Springer. p. 185. ISBN 978-3-030-12281-2. Archived from the original on 9 November 2021. Retrieved 9 November 2021.
  6. ^ "Orphenadrine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 12 July 2021. Retrieved 9 November 2021.
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