User:Mr. Ibrahem/Pancuronium
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| Clinical data | |
|---|---|
| Other names | Pancuronium bromide |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
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| Routes of administration | Intravenous |
| Drug class | Neuromuscular blocking agent[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | 77 to 91% |
| Metabolism | Liver |
| Onset of action | 2 to 3 min[2] |
| Elimination half-life | 1.5 to 2.7 hours |
| Duration of action | Up to 100 min[2] |
| Excretion | Kidney and biliary |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C35H60N2O4 |
| Molar mass | 572.875 g·mol−1 |
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  (what is this?) (verify) | |
Pancuronium, sold under the brand name Pavulon, is a medication used to relax muscles during general anesthesia, when a person is being ventilated, and to help with endotracheal intubation.[2] It is given by injection into a vein.[2] Onset is relatively slow at 2 to 3 minutes while effects can last for up to 100 minutes.[2]
Common side effects include muscle weakness.[2] Other side effects may include anaphylaxis and increased heart rate.[2] Use in pregnancy appears to be safe, but is not well studied.[3] Neostigmine or pyridostigmine may be used to reverse its affects.[1] It is a neuromuscular blocking agent.[1]
Pancuronium was first made in 1964 and approved for medical use in the United States in 1972.[2][1] It is available as a generic medication.[4] In the United Kingdom it costs the NHS about £5 per 4 mg as of 2021.[4] This amount is about 3 USD in the United States.[5] It has been used in euthanasia and during lethal injection.[6][7]
References[edit]
- ^ a b c d Das GN, Sharma P, Maani CV (January 2021). "Pancuronium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30855929. Archived from the original on 2021-01-04. Retrieved 2021-08-22.
- ^ a b c d e f g h i j k "Pancuronium Monograph for Professionals". Drugs.com. Archived from the original on 5 October 2021. Retrieved 26 October 2021.
- ^ "Pancuronium (Pavulon) Use During Pregnancy". Drugs.com. Archived from the original on 30 November 2020. Retrieved 26 October 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1391. ISBN 978-0857114105.
- ^ "Pancuronium Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 May 2019. Retrieved 26 October 2021.
- ^ "US court backs lethal injection". BBC News. 16 April 2008. Archived from the original on 20 April 2008. Retrieved 22 August 2021.
- ^ "Administration and Compounding Of Euthanasic Agents". The Hague: Royal Dutch Society for the Advancement of Pharmacy. Archived from the original on 7 June 2008. Retrieved 15 July 2008 – via ERGO!.