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User:Mr. Ibrahem/Pegvaliase

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Mr. Ibrahem/Pegvaliase
Clinical data
Pronunciationpeg val' i ase
Trade namesPalynziq
Other namesPegvaliase-pqpz; PEG-PAL; RAvPAL-PEG
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		Subcutaneous
Drug classEnzyme[2]
Legal status
Legal status
Identifiers
  • (2S)-2-amino-6-[6-(2-methoxyethoxy)hexanamido]hexanoic acid
Chemical and physical data
FormulaC15H30N2O5
Molar mass318.414 g·mol−1
3D model (JSmol)
  • COCCOCCCCCC(=O)NCCCC[C@H](N)C(O)=O
  • InChI=1S/C15H30N2O5/c1-21-11-12-22-10-6-2-3-8-14(18)17-9-5-4-7-13(16)15(19)20/h13H,2-12,16H2,1H3,(H,17,18)(H,19,20)/t13-/m0/s1
  • Key:NPOCDVAOUKODSQ-ZDUSSCGKSA-N

Pegvaliase, sold under the brand name Palynziq, is a medication used to treat phenylketonuria.[2] It is used when other treatments, including diet and sapropterin, are not sufficient.[2][3] It is given by injection under the skin.[3]

Common side effects include pain at the site of injection, joint pain, and allergic reactions.[2] Other side effects may include anaphylaxis, angioedema, and serum sickness.[2][3] It is unclear if use during pregnancy is safe for the baby.[3] It is the enzyme phenylalanine ammonia lyase connected to polyethylene glycol and works by breaking down phenylalanine.[2][3]

Pegvaliase was approved for medical use in the United States in 2018 and Europe in 2019.[3][2] It is not available in the United Kingdom as of 2021.[4] In the United States it costs about 560 USD per dose up to 20 mg as of 2021.[5]

References[edit]

  1. ^ a b "Palynziq". Therapeutic Goods Administration (TGA). 23 July 2021. Archived from the original on 5 September 2021. Retrieved 5 September 2021.
  2. ^ a b c d e f g h i "Palynziq". Archived from the original on 20 October 2021. Retrieved 27 October 2021.
  3. ^ a b c d e f "Pegvaliase-pqpz Monograph for Professionals". Drugs.com. Retrieved 27 October 2021.
  4. ^ "Pegvaliase". SPS - Specialist Pharmacy Service. 31 March 2015. Archived from the original on 27 October 2021. Retrieved 27 October 2021.
  5. ^ "Palynziq Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 January 2021. Retrieved 27 October 2021.
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