User:Mr. Ibrahem/Phentermine

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Mr. Ibrahem/Phentermine
Clinical data
Trade namesAdipex-p, Duromine, Metermine, Suprenza, others
Other namesα-methyl-amphetamine
α,α-dimethylphenethylamine
AHFS/Drugs.comMonograph
MedlinePlusa682187
License data
Pregnancy
category
  • AU: B3
Dependence
liability		Limited[1]
Addiction
liability		Low[2]
Routes of
administration		By mouth
Drug classAppetite suppressant[3]
Legal status
Legal status
Pharmacokinetic data
BioavailabilityHigh (almost complete)[4]
Protein bindingApproximately 96.3%
MetabolismLiver[4]
Elimination half-life25 hours, urinary pH-dependent[4]
ExcretionUrinary (62–85% unchanged)[4]
Identifiers
  • 2-methyl-1-phenylpropan-2-amine
Chemical and physical data
FormulaC10H15N
Molar mass149.237 g·mol−1
3D model (JSmol)
  • NC(Cc1ccccc1)(C)C
  • InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3 checkY
  • Key:DHHVAGZRUROJKS-UHFFFAOYSA-N checkY
  (verify)

Phentermine (phenyl-tertiary-butylamine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat obesity.[3] It is taken by mouth for up to a few weeks.[3] After a few weeks the beneficial effects no longer occur.[3] It is also available as the combination phentermine/topiramate.[6]

Common side effects include a fast heart beat, high blood pressure, trouble sleeping, dizziness, and restlessness.[3] Serious side effects may include pulmonary hypertension, valvular heart disease, and abuse.[3] Use is not recommended during pregnancy or breastfeeding.[7] Use is not recommended together with SSRIs or MAO inhibitors.[3] It works as an appetite suppressant likely as a result of being a CNS stimulant.[3] Chemically, phentermine is a substituted amphetamine.[8]

Phentermine was approved for medical use in the United States in 1959.[3] It is available as a generic medication.[3] The wholesale cost of a month supply in the United States is about US$2.55.[9] In 2017, it was the 210th most commonly prescribed medication in the United States, with more than two million prescriptions.[10][11] Phentermine was withdrawn from the market in the United Kingdom in 2000 while the combination medication fen-phen, of which it was a part, was withdrawn from the market in 1997 due to side effects.[12]

References[edit]

  1. ^ Tarascon Pocket Pharmacopoeia 2017 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. 2016. p. 7. ISBN 9781284118971. Archived from the original on 9 July 2021. Retrieved 13 April 2019.
  2. ^ Sadock, Benjamin J.; Sadock, Virginia A. (2010). Kaplan and Sadock's Pocket Handbook of Clinical Psychiatry. 435: Lippincott Williams & Wilkins. ISBN 9781605472645. Archived from the original on 9 July 2021. Retrieved 13 April 2019.{{cite book}}: CS1 maint: location (link)
  3. ^ a b c d e f g h i j k l "Phentermine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 7 June 2019. Retrieved 13 April 2019.
  4. ^ a b c d "METERMINE (Phentermine)" (PDF). TGA eBusiness Services. iNova Pharmaceuticals (Australia) Pty Limited. 22 July 2013. Archived from the original on 13 October 2016. Retrieved 16 November 2013.
  5. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 28 November 2020. Retrieved 9 September 2020.
  6. ^ "Phentermine and topiramate Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 13 April 2019. Retrieved 13 April 2019.
  7. ^ "Phentermine Use During Pregnancy". Drugs.com. Archived from the original on 13 April 2019. Retrieved 13 April 2019.
  8. ^ Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ (2012). "Biosynthesis of amphetamine analogs in plants". Trends Plant Sci. 17 (7): 404–412. doi:10.1016/j.tplants.2012.03.004. PMID 22502775.
  9. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  10. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  11. ^ "Phentermine - Drug Usage Statistics". ClinCalc. Archived from the original on 22 September 2020. Retrieved 11 April 2020.
  12. ^ Bagchi, Debasis; Preuss, Harry G. (2012). Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition. CRC Press. p. 314. ISBN 9781439854259. Archived from the original on 9 July 2021. Retrieved 13 April 2019.
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