User:Mr. Ibrahem/Plazomicin

Plazomicin
Clinical data
Trade names	Zemdri
Other names	ACHN-490,; 6'-(Hydroxylethyl)-1-(HABA)-sisomicin
AHFS/Drugs.com	Monograph
MedlinePlus	a618037
License data	US DailyMed: Plazomicin; US FDA: Zemdri;
Routes of; administration	Intravenous infusion
Drug class	Aminoglycoside antibiotic
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[[(2S,3R)-3-amino-6-[(2-hydroxyethylamino)methyl]-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;
Chemical and physical data
Formula	C25H48N6O10
Molar mass	592.691 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(=CC[C@H]3N)CNCCO)[C@@H](N)C[C@H]2NC(=O)[C@@H](O)CCN)OC[C@]1(C)O;
	InChI InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1; Key:IYDYFVUFSPQPPV-PEXOCOHZSA-N;

Plazomicin, sold under the brand name Zemdri, is an aminoglycoside antibiotic used to treat complicated urinary tract infections.^[1] As of 2019 it is recommended only for those in whom alternatives are not an option.^[1] It is given by injection into a vein.^[1]

Common side effects include kidney problems, diarrhea, nausea, and blood pressure changes.^[1] Other severe side effects include hearing loss, Clostridium difficile-associated diarrhea, anaphylaxis, and muscle weakness.^[1] Use during pregnancy may harm the baby.^[1] Plazomicin works by decreasing the ability of bacteria to make protein.^[1]

Plazomicin was approved for medical use in the United States in 2018.^[3]^[4] It is on the World Health Organization's List of Essential Medicines.^[5] The price of 10 days of treatment in the United States costs about US$6,600.^[6]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 August 2020. Retrieved 10 October 2019.
^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 6 August 2020. Retrieved 11 September 2020.
^ "FDA Approved Drug Products: Zemdri". U.S. Food and Drug Administration. Archived from the original on 28 November 2020. Retrieved 28 June 2018.
^ "Drug Approval Package: Zemdri (plazomicin)". U.S. Food and Drug Administration. 5 July 2018. Archived from the original on 28 November 2020. Retrieved 25 December 2019.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. hdl:10665/325771.
^ "Zemdri Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 October 2019. Retrieved 10 October 2019.