User:Mr. Ibrahem/Rabies immunoglobulin
| Clinical data | |
|---|---|
| Trade names | Imogam Rabies-HT, Kedrab, HyperRab, others |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
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| Legal status | |
| Legal status | |
Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus.[8] It is used to prevent rabies following exposure.[8] It is given after the wound is cleaned with soap and water or povidone-iodine and is followed by a course of rabies vaccine.[8] It is given by injection into the site of the wound and into a muscle.[8] It is not needed in people who have been previously vaccinated against rabies.[9]
Common side effects include pain at the site of injection, fever, and headache.[8] Severe allergic reactions such as anaphylaxis may rarely occur.[10] Use during pregnancy is not known to harm the baby.[8] It works by binding to the rabies virus before it can enter nerve tissue.[8] After the virus has entered the central nervous system, rabies immunoglobulin is no longer useful.[8]
The use of rabies immunoglobulin in the form of blood serum dates from 1891.[11] Use became common within medicine in the 1950s.[12] It is on the World Health Organization's List of Essential Medicines.[13] Rabies immunoglobulin is expensive and hard to come by in the developing world.[14] In the United States it is estimated to be more than US$1,000 per dose.[15] Some versions are made from the blood plasma of people or horses who have high levels of the antibody in their blood.[8][15] The horse version is less expensive but has a higher rate of side effects.[15][12] A number of monoclonal antibody versions are also avaialble.[16]
References[edit]
- ^ a b "Kamrab". Therapeutic Goods Administration (TGA). 23 August 2021. Archived from the original on 10 September 2021. Retrieved 10 September 2021.
- ^ "Kamrab PI". Health Canada. 25 April 2012. Archived from the original on 11 September 2021. Retrieved 10 September 2021.
- ^ "Imogam Rabies-HT - human rabies virus immune globulin injection, solution". DailyMed. Archived from the original on 20 October 2020. Retrieved 24 March 2020.
- ^ "Kedrab- human rabies virus immune globulin injection, solution". DailyMed. Archived from the original on 7 August 2020. Retrieved 24 March 2020.
- ^ "Hyperrab (rabies immune globulin- human injection, solution". DailyMed. Archived from the original on 22 October 2019. Retrieved 24 March 2020.
- ^ "Hyperrab S/D (rabies immune globulin- human injection". DailyMed. Archived from the original on 10 September 2021. Retrieved 10 September 2021.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 24 September 2020. Retrieved 15 September 2020.
- ^ a b c d e f g h i "Rabies Immune Globulin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
- ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 398. hdl:10665/44053. ISBN 9789241547659.
- ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 869. ISBN 9780857111562.
- ^ Plotkin, [edited by] Stanley A.; Orenstein, Walter A.; Offit, Paul A. (2013). Vaccines (6th ed.). [Edinburgh]: Elsevier/Saunders. p. 659. ISBN 978-1455700905. Archived from the original on 2017-01-09.
{{cite book}}:|first1=has generic name (help) - ^ a b Jong, Elaine C.; Zuckerman, Jane N. (2004). Travelers' Vaccines. PMPH-USA. p. 205. ISBN 9781550092257. Archived from the original on 2017-01-09.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ Tintinalli, Judith E. (2010). Emergency Medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli)) (7 ed.). New York: McGraw-Hill Companies. p. 1054. ISBN 978-0-07-148480-0.
- ^ a b c Research Advances in Rabies. Academic Press. 2011. p. 351. ISBN 9780123870414. Archived from the original on 2017-01-09.
- ^ Fan, L; Zhang, L; Li, J; Zhu, F (31 December 2022). "Advances in the progress of monoclonal antibodies for rabies". Human vaccines & immunotherapeutics. 18 (1): 2026713. doi:10.1080/21645515.2022.2026713. PMID 35172707.