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User:Mr. Ibrahem/Ramipril

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Mr. Ibrahem/Ramipril
Clinical data
Trade namesAltace, others
AHFS/Drugs.comMonograph
MedlinePlusa692027
License data
Pregnancy
category
  • D
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability28%
Protein binding73% (ramipril)
56% (ramiprilat)
MetabolismLiver, to ramiprilat
Elimination half-life13 to 17 hours
ExcretionKidney (60%) and fecal (40%)
Identifiers
  • (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
Chemical and physical data
FormulaC23H32N2O5
Molar mass416.518 g·mol−1
3D model (JSmol)
Melting point109 °C (228 °F)
  • O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCC[C@H]12)C)CCc3ccccc3
  • InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1 checkY
  • Key:HDACQVRGBOVJII-JBDAPHQKSA-N checkY
  (verify)

Ramipril, sold under the brand name Altace among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[2] Also used to prevent cardiovascular disease in those at high risk.[2] It is a reasonable initial treatment for high blood pressure.[2] It is taken by mouth.[2]

Common side effects include headaches, dizziness, feeling tired, and cough.[2] Serious side effects may include liver problems, angioedema, kidney problems, and high blood potassium.[2] Use in pregnancy and breastfeeding is not recommended.[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[2]

Ramipril was patented in 1981 and approved for medical use in 1989.[4] It is available as a generic medication.[5] A month supply in the United Kingdom costs the NHS less than £1 as of 2020.[5] In the United States, the wholesale cost of this amount is about US$2.[6] In 2017, it was the 134th most commonly prescribed medication in the United States, with more than five million prescriptions.[7][8]

References

[edit]
  1. ^ Cite error: The named reference WHO2020DDD was invoked but never defined (see the help page).
  2. ^ a b c d e f g "Ramipril Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 June 2019. Retrieved 3 March 2019.
  3. ^ "Ramipril Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 13 October 2017. Retrieved 3 March 2019.
  4. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495. Archived from the original on 1 March 2019. Retrieved 1 March 2019.
  5. ^ a b BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 184–185. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  6. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  7. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  8. ^ "Ramipril - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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