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User:Mr. Ibrahem/Rho(D) immune globulin

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Mr. Ibrahem/Rho(D) immune globulin
Clinical data
Trade namesWinRho, RhoGAM, others
Other namesRh0(D) immune globulin; anti-D (Rh0) immunoglobulin; immunoglobulinum humanum anti–D
AHFS/Drugs.comMonograph
Pregnancy
category
  • C
Routes of
administration		Intramuscular injection
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Rho(D) immune globulin (RhIG) is a medication used to prevent RhD isoimmunization in mothers who are RhD negative and to treat idiopathic thrombocytopenic purpura (ITP) in people who are Rh positive.[1] It is often given both during and following pregnancy.[1] It may also be used when RhD negative people are given RhD positive blood.[1] It is given by injection into muscle or a vein.[1] A single dose lasts 12 weeks.[1]

Common side effects include fever, headache, pain at the site of injection, and red blood cell breakdown.[1] Other side effects include allergic reactions, kidney problems, and a very small risk of viral infections.[1] In those with ITP, the amount of red blood cell breakdown may be significant.[1] Use is safe with breastfeeding.[1] Rho(D) immune globulin is made up of antibodies to the antigen Rho(D) present on some red blood cells.[1] It is believed to work by blocking a person's immune system from recognizing this antigen.[1]

Rho(D) immune globulin came into medical use in the 1960s.[3] It is on the World Health Organization's List of Essential Medicines.[4] In the United Kingdom, a 500-unit (100-mcg) vial costs the NHS around £40.[5] In the United States, a course of treatment costs more than $200.[6] It is made from human blood plasma.[5]

References

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  1. ^ a b c d e f g h i j k l m "Rho(D) Immune Globulin". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 14 September 2020.
  3. ^ Hatfield, Nancy T. (2007). Broadribb's Introductory Pediatric Nursing. Lippincott Williams & Wilkins. p. 251. ISBN 9780781777063. OCLC 968617246. Archived from the original on 2020-09-22. Retrieved 2020-06-30 – via Google Books.
  4. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. ^ a b "14. Vaccines". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. pp. 1344–1345. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)
  6. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 368. ISBN 9781284057560.
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