User:Mr. Ibrahem/Riluzole

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Mr. Ibrahem/Riluzole
Clinical data
Trade namesRilutek, Tiglutik, Exservan, others
AHFS/Drugs.comMonograph
MedlinePlusa696013
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability60±18%[1]
Protein binding97%[1]
MetabolismLiver (CYP1A2)[1]
Elimination half-life9–15 hours[1]
ExcretionUrine (90%)[1]
Identifiers
  • 6-(trifluoromethoxy)benzothiazol-2-amine
Chemical and physical data
FormulaC8H5F3N2OS
Molar mass234.20 g·mol−1
3D model (JSmol)
  • FC(F)(F)Oc1ccc2nc(sc2c1)N
  • InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) checkY
  • Key:FTALBRSUTCGOEG-UHFFFAOYSA-N checkY
  (verify)

Riluzole, sold under the brand name Rilutek among others, is a medication used to treat amyotrophic lateral sclerosis.[2] It delays the need for a ventilator or tracheostomy and improves survival by two to three months.[4] It is taken by mouth, either as a tablet or liquid.[5]

Common side effects include weakness and liver problems.[3] Other side effects may include anaphylaxis, interstitial lung disease, and low neutrophils.[2] How it works is unclear, but may be due to a decrease in glutamate in the nervous system.[3]

Riluzole was approved for medical use in the United States in 1995 and Europe in 1996.[2][3] It is available as a generic medication.[5] In the United Kingdom 4 weeks costs the NHS about £23 as of 2021.[5] This amount in the United States is about 33 USD.[6]

References[edit]

  1. ^ a b c d e "PRODUCT INFORMATION RILUTEK® (riluzole) Tablets" (PDF). TGA eBusiness Services. sanofi-aventis australia pty ltd. January 6, 2009. Archived from the original on March 17, 2018. Retrieved February 18, 2014.
  2. ^ a b c d "Riluzole Monograph for Professionals". Drugs.com. Archived from the original on August 10, 2020. Retrieved October 17, 2021.
  3. ^ a b c d "Rilutek". Archived from the original on December 27, 2020. Retrieved October 17, 2021.
  4. ^ Miller, RG; Mitchell, JD; Moore, DH (March 14, 2012). "Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)". The Cochrane Database of Systematic Reviews. 3 (3): CD001447. doi:10.1002/14651858.CD001447.pub3. PMC 7055506. PMID 22419278.
  5. ^ a b c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1186. ISBN 978-0-85711-369-6.
  6. ^ "Riluzole Prices and Riluzole Coupons - GoodRx". GoodRx. Retrieved October 17, 2021.
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