User:Mr. Ibrahem/Rivastigmine
Clinical data | |
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Trade names | Exelon, Prometax, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a602009 |
License data |
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Pregnancy category |
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Routes of administration | By mouth, transdermal patch |
Drug class | Cholinesterase inhibitor[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 60 to 72% |
Protein binding | 40% |
Metabolism | Liver, via pseudocholinesterase |
Elimination half-life | 1.5 hours |
Excretion | 97% in urine |
Identifiers | |
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Chemical and physical data | |
Formula | C14H22N2O2 |
Molar mass | 250.342 g·mol−1 |
3D model (JSmol) | |
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Rivastigmine, sold under the brand name Exelon among others, is a medication used to treat dementia in Alzheimer's or Parkinson's.[1] Benefits are modest and use does not affect the underlying disease.[1] It is taken by mouth or via a skin patch.[1]
Common side effects include nausea, confusion, hallucinations, and problems sleeping.[2][3] Other side effects may include slow heart rate, urinary obstruction, seizures, and allergic dermatitis.[1] It is a cholinesterase inhibitor which increases acetylcholine in the brain.[1]
Rivastigmine was patented in 1985 and came into medical use in 1997.[4] It was approved for medical use in Europe in 1998 and the United States in 2000.[3][1] It is available as a generic medication.[2] In the United Kingdom it costs about £5 per month for the pills as of 2021.[2] In the United States this amount costs about 27 USD.[5]
References[edit]
- ^ a b c d e f g h "Rivastigmine Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 October 2021.
- ^ a b c d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 319. ISBN 978-0-85711-369-6.
{{cite book}}
: CS1 maint: date format (link) - ^ a b c d e "Prometax". Archived from the original on 22 June 2021. Retrieved 18 October 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 540. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-05-11.
- ^ "Rivastigmine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 October 2021.