User:Mr. Ibrahem/Rivastigmine

Mr. Ibrahem/Rivastigmine
Clinical data
Trade names	Exelon, Prometax, others
AHFS/Drugs.com	Monograph
MedlinePlus	a602009
License data	EU EMA: by INN; US DailyMed: Rivastigmine;
Pregnancy; category	AU: B2; ;
Routes of; administration	By mouth, transdermal patch
Drug class	Cholinesterase inhibitor
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	60 to 72%
Protein binding	40%
Metabolism	Liver, via pseudocholinesterase
Elimination half-life	1.5 hours
Excretion	97% in urine
Identifiers
	IUPAC name (S)-3-[1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate;
Chemical and physical data
Formula	C14H22N2O2
Molar mass	250.342 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Oc1cc(ccc1)[C@@H](N(C)C)C)N(CC)C;
	InChI InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1 ; Key:XSVMFMHYUFZWBK-NSHDSACASA-N ;
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Rivastigmine, sold under the brand name Exelon among others, is a medication used to treat dementia in Alzheimer's or Parkinson's.^[1] Benefits are modest and use does not affect the underlying disease.^[1] It is taken by mouth or via a skin patch.^[1]

Common side effects include nausea, confusion, hallucinations, and problems sleeping.^[2]^[3] Other side effects may include slow heart rate, urinary obstruction, seizures, and allergic dermatitis.^[1] It is a cholinesterase inhibitor which increases acetylcholine in the brain.^[1]

Rivastigmine was patented in 1985 and came into medical use in 1997.^[4] It was approved for medical use in Europe in 1998 and the United States in 2000.^[3]^[1] It is available as a generic medication.^[2] In the United Kingdom it costs about £5 per month for the pills as of 2021.^[2] In the United States this amount costs about 27 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Rivastigmine Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 October 2021.
^ ^a ^b ^c ^d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 319. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b ^c ^d ^e "Prometax". Archived from the original on 22 June 2021. Retrieved 18 October 2021.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 540. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-05-11.
^ "Rivastigmine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Rivastigmine Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 October 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 319. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EPAR2021-3] "Prometax". Archived from the original on 22 June 2021. Retrieved 18 October 2021.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 540. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-05-11.

[5] "Rivastigmine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 October 2021.

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