User:Mr. Ibrahem/Ropivacaine

Mr. Ibrahem/Ropivacaine
Clinical data
Pronunciation	/roʊˈpɪvəkeɪn/
Trade names	Naropin
Other names	Ropivacaine hydrochloride
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: B1; ;
Routes of; administration	Parenteral
Drug class	Local anesthetic (amide)
Legal status
Legal status	AU: S4 (Prescription only);
Pharmacokinetic data
Bioavailability	87%–98% (epidural)
Metabolism	Liver (CYP1A2-mediated)
Elimination half-life	1.6–6 hours (varies with administration route)
Excretion	Kidney 86%
Identifiers
	IUPAC name (S)-N-(2,6-dimethylphenyl)-; 1-propylpiperidine-2-carboxamide;
Chemical and physical data
Formula	C17H26N2O
Molar mass	274.408 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	144 to 146 °C (291 to 295 °F)
	SMILES O=C(Nc1c(cccc1C)C)[C@H]2N(CCC)CCCC2;
	InChI InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1 ; Key:ZKMNUMMKYBVTFN-HNNXBMFYSA-N ;
	(verify)

Ropivacaine, sold under the brand name Naropin, is a local anesthetic.^[1] It may be injected into an area, used for a nerve block, or given during an epidural.^[1]

Common side effects include nausea, slow heart rate, low blood pressure, pain and itchiness.^[1] Other side effects may include arrhythmia and abnormal sensation.^[2] Use during pregnancy appears to be safe for the baby but has not been well studied.^[3] It appears to have less heart and neurological side effects.^[1] It belonging to amide group.^[1]

Ropivacaine was approved for medical use in the United States in 1996.^[1] It is available as a generic medication.^[2] In the United States a 200 ml of 0.2% solution costs about 100 USD.^[4] This amount in the United Kingdom costs about £14.^[2]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Ropivacaine Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 18 October 2021.
^ ^a ^b ^c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1428. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Ropivacaine Use During Pregnancy". Drugs.com. Archived from the original on 28 January 2021. Retrieved 18 October 2021.
^ "Naropin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 18 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Ropivacaine Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 18 October 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1428. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[3] "Ropivacaine Use During Pregnancy". Drugs.com. Archived from the original on 28 January 2021. Retrieved 18 October 2021.

[4] "Naropin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 18 October 2021.

[1]

[2]

[3]

[4]