User:Mr. Ibrahem/Rotigotine

Mr. Ibrahem/Rotigotine
Clinical data
Trade names	Neupro, Leganto
AHFS/Drugs.com	Monograph
MedlinePlus	a607059
License data	EU EMA: by INN; US DailyMed: Rotigotine;
Pregnancy; category	AU: B3; ;
Routes of; administration	Transdermal patch
Drug class	Dopamine agonist
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	37% (transdermal)
Protein binding	92%
Metabolism	Liver (CYP-mediated)
Elimination half-life	5–7 hours
Excretion	Urine (71%), Fecal (23%)
Identifiers
	IUPAC name (S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8- tetrahydronaphthalen-1-ol;
Chemical and physical data
Formula	C19H25NOS
Molar mass	315.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cccc3c1CCC(N(CCC)CCc2sccc2)C3;
	InChI InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3 ; Key:KFQYTPMOWPVWEJ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Rotigotine, sold under the brand name Neupro among others, used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).^[1] It comes as a once-daily skin patch.^[1]

Common side effects include nausea, sleepiness, increased sweating, anxiety, and swelling.^[1] Other side effects may include anaphylaxis, sleep attacks, psychosis, compulsive gambling, and weight gain.^[1] There are concerns regarding safety in pregnancy.^[2] It is a dopamine agonist of the non-ergoline class.^[1]

Rotigotine was approved for medical use in Europe in 2006 and the United States in 2007.^[3]^[1] In the United States it costs about 750 USD per month as of 2021.^[4] In the United Kingdom this amount costs the NHS about £130.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Rotigotine Monograph for Professionals". Drugs.com. Archived from the original on 2 May 2021. Retrieved 19 October 2021.
^ "Rotigotine (Neupro) Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 19 October 2021.
^ "Neupro". Archived from the original on 2 March 2020. Retrieved 19 October 2021.
^ "Neupro Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 19 October 2021.
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 446. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Rotigotine Monograph for Professionals". Drugs.com. Archived from the original on 2 May 2021. Retrieved 19 October 2021.

[2] "Rotigotine (Neupro) Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 19 October 2021.

[EPAR2021-3] "Neupro". Archived from the original on 2 March 2020. Retrieved 19 October 2021.

[4] "Neupro Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 19 October 2021.

[BNF80-5] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 446. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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