User:Mr. Ibrahem/Rufinamide

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Not to be confused with ralfinamide.
Mr. Ibrahem/Rufinamide
Clinical data
Trade namesBanzel, Inovelon
AHFS/Drugs.comMonograph
MedlinePlusa609001
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth (tablets)
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability85% (under fed conditions); tmax = 4–6 hours
Protein binding34%
MetabolismCarboxylesterase-mediated hydrolysis (CYP not involved)
MetabolitesInactive
Elimination half-life6–10 hours
ExcretionUrine (85%)[1]
Identifiers
  • 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
Chemical and physical data
FormulaC10H8F2N4O
Molar mass238.198 g·mol−1
3D model (JSmol)
  • O=C(c1nnn(c1)Cc2c(F)cccc2F)N
  • InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) checkY
  • Key:POGQSBRIGCQNEG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Rufinamide, sold under the brand name Banzel among others, is a medication used to treat Lennox–Gastaut syndrome and partial seizures not controlled by other measures.[2] It is taken by mouth.[2]

Common side effects include sleepiness, headache, dizziness, and vomiting.[3] Other symptoms may include drug reaction with eosinophilia and systemic symptoms, suicide, and poor coordination.[2] Safety in pregnancy is unclear.[4] It is a triazole derivative that is believed to work by attaching to sodium channels in the brain.[3][2]

Rufinamide was approved for medical use in Europe in 2007 and the United States in 2008.[3][2] It is available as a generic medication.[5] In the United Kingdom a dose of 800 mg per day costs the NHS costs about £100.[6] In the United States this amount costs about 425 USD per month.[5]

References[edit]

  1. ^ a b "Banzel- rufinamide tablet, film coated Banzel- rufinamide suspension". DailyMed. 15 April 2020. Archived from the original on 26 October 2020. Retrieved 21 October 2020.
  2. ^ a b c d e f "Rufinamide Monograph for Professionals". Drugs.com. Archived from the original on 30 September 2021. Retrieved 19 October 2021.
  3. ^ a b c d "Inovelon". Archived from the original on 20 May 2021. Retrieved 19 October 2021.
  4. ^ "Rufinamide (Banzel) Use During Pregnancy". Drugs.com. Archived from the original on 4 October 2021. Retrieved 19 October 2021.
  5. ^ a b "Rufinamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 October 2021. Retrieved 19 October 2021.
  6. ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 343. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
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