User:Mr. Ibrahem/Salmeterol

Mr. Ibrahem/Salmeterol
Clinical data
Trade names	Serevent, Aeromax, others
Other names	Salmeterol xinafoate
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US DailyMed: Salmeterol;
Pregnancy; category	AU: B3; ;
Routes of; administration	Respiratory inhalation (Metered-dose inhaler (MDI), Dry-powder inhaler (DPI))
Drug class	Long-acting β2 adrenergic receptor agonist (LABA)
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	96%
Metabolism	Liver (CYP3A4)
Onset of action	About 30 min
Elimination half-life	5.5 hours
Duration of action	12 hr
Identifiers
	IUPAC name (RS)-2-(hydroxymethyl)-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol;
Chemical and physical data
Formula	C25H37NO4
Molar mass	415.574 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES OCc1cc(ccc1O)[C@H](O)CNCCCCCCOCCCCc2ccccc2;
	InChI InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2/t25-/m1/s1 ; Key:GIIZNNXWQWCKIB-RUZDIDTESA-N ;
	(what is this?) (verify)

Salmeterol, sold under the brand name Serevent among others, is a medication used in the maintenance of asthma or chronic obstructive pulmonary disease (COPD).^[1] In asthma it is used together with a inhaled corticosteroid.^[1] It is also used for exercise-induced bronchoconstriction.^[1] Effects may begin in about 30 min and last about 12 hours.^[1]^[3]

Common side effects include headache, runny nose, thrush, cough, and change in voice.^[1] Other side effects may include low potassium, anaphylaxis, bronchospasm, and QT prolongation.^[1] Use during pregnancy or breastfeeding is deemed reasonable.^[3] It is a long-acting β₂ adrenergic receptor agonist (LABA).^[1]

Salmeterol was patented in 1983 and came into medical use in 1990.^[4] In the United Kingdom 120 doses costs the NHS about £30 in 2021.^[3] This amount in the United States costs about 800 USD.^[5] It is also avaliable as fluticasone/salmeterol.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Salmeterol". American Society of Health-System Pharmacists. Archived from the original on 25 July 2021. Retrieved 10 October 2021.
^ "Serevent Diskus- salmeterol xinafoate powder, metered". DailyMed. 13 January 2020. Archived from the original on 14 December 2020. Retrieved 6 September 2020.
^ ^a ^b ^c ^d ^e BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 266. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 543. ISBN 9783527607495. Archived from the original on 2021-07-24. Retrieved 2021-06-21.
^ "Salmeterol Xinafoate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Salmeterol". American Society of Health-System Pharmacists. Archived from the original on 25 July 2021. Retrieved 10 October 2021.

[Serevent_FDA_label-2] "Serevent Diskus- salmeterol xinafoate powder, metered". DailyMed. 13 January 2020. Archived from the original on 14 December 2020. Retrieved 6 September 2020.

[BNF80-3] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 266. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Fis2006-4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 543. ISBN 9783527607495. Archived from the original on 2021-07-24. Retrieved 2021-06-21.

[5] "Salmeterol Xinafoate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 October 2021.

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