User:Mr. Ibrahem/Sonidegib

Mr. Ibrahem/Sonidegib
Clinical data
Trade names	Odomzo
Other names	LDE225, erismodegib
AHFS/Drugs.com	Monograph
MedlinePlus	a615034
License data	EU EMA: by INN; US DailyMed: Sonidegib;
Pregnancy; category	AU: X (High risk); Contraindicated;
Routes of; administration	By mouth (capsules)
Drug class	Antineoplastic agents (hedgehog pathway inhibitor)
Legal status
Legal status	US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	<10%
Protein binding	>97%
Metabolism	Liver (CYP3A)
Elimination half-life	~28 days
Excretion	Feces (~70%), urine (30%)
Identifiers
	IUPAC name N-[6-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide;
Chemical and physical data
Formula	C26H26F3N3O3
Molar mass	485.507 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F;
	InChI InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+; Key:VZZJRYRQSPEMTK-CALCHBBNSA-N;

Sonidegib, sold under the brand name Odomzo, is a medication used to treat cancer, specifically basal cell skin cancer.^[2] It is used in cases in which surgery or radiation therapy has failed or is not an option.^[2] It is taken by mouth.^[2]

Common side effects include muscle spasms, hair loss, taste changes, tiredness, nausea, pain, diarrhea, vomiting, and itchiness.^[2] Other side effects may include muscle breakdown and liver problems.^[3] Use before or during pregnancy may harm the baby.^[2] It is a hedgehog signaling pathway inhibitor.^[2]^[3]

Sonidegib was approved for medical use in the United States and in the European Union in 2015.^[2]^[4] In the United States it costs about 13,000 USD per month.^[5]

References[edit]

^ ^a ^b "Sonidegib (Odomzo) Use During Pregnancy". Drugs.com. 17 May 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Odomzo- sonidegib capsule". DailyMed. 29 May 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.
^ ^a ^b "Sonidegib Monograph for Professionals". Drugs.com. Archived from the original on 9 June 2020. Retrieved 14 October 2021.
^ "Odomzo". European Medicines Agency. 17 September 2018. Archived from the original on 9 June 2020. Retrieved 9 June 2020.
^ "Odomzo Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 October 2021.

[Drugs.com_pregnancy-1] "Sonidegib (Odomzo) Use During Pregnancy". Drugs.com. 17 May 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.

[PI2021-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Odomzo- sonidegib capsule". DailyMed. 29 May 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.

[AHFS2021-3] "Sonidegib Monograph for Professionals". Drugs.com. Archived from the original on 9 June 2020. Retrieved 14 October 2021.

[EPAR2021-4] "Odomzo". European Medicines Agency. 17 September 2018. Archived from the original on 9 June 2020. Retrieved 9 June 2020.

[5] "Odomzo Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 October 2021.

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