User:Mr. Ibrahem/Tacalcitol

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Mr. Ibrahem/Tacalcitol
Clinical data
Trade namesCuratoderm, Bonalfa, others
Other names(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Applied to the skin[1]
Drug classVitamin D3 analog[2]
Identifiers
  • (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
Chemical and physical data
FormulaC27H44O3
Molar mass416.64 g·mol−1
3D model (JSmol)
  • O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
  • InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ☒N
  • Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tacalcitol sold under the brand names Curatoderm among others, is a medication used to treat psoriasis, specifically plaque psoriasis.[1][3] It is applied to the skin once to twice per day.[1][2]

Side effects may include skin rash and high calcium.[1] It is a manufactured vitamin D3 analog.[2]

Tacalcitol was approved for medical use in Japan in 1993.[4] It is on the World Health Organization's List of Essential Medicines as an alternative to calcipotriol.[5] In the United Kingdom 30 grams costs the NHS about £13 as of 2023.[6]

References[edit]

  1. ^ a b c d e f "Tacalcitol". NICE. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
  2. ^ a b c Peters DC, Balfour JA (August 1997). "Tacalcitol". Drugs. 54 (2): 265–71, discussion 272. doi:10.2165/00003495-199754020-00005. PMID 9257082.
  3. ^ "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 10 June 2023. Retrieved 9 September 2023.
  4. ^ Tarutani, M (October 2004). "[Vitamin D3 for external application--history of development and clinical application]". Clinical calcium. 14 (10): 124–8. PMID 15577144.
  5. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  6. ^ "Tacalcitol Medicinal forms". NICE. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
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