User:Mr. Ibrahem/Tadalafil
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| Clinical data | |
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| Pronunciation | /təˈdæləfɪl/ tə-DAL-ə-fil |
| Trade names | Cialis, Adcirca, Tadacip, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604008 |
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| Routes of administration | By mouth (tablets) |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | Varies |
| Protein binding | 94% |
| Metabolism | Liver (predominantly CYP3A4) |
| Metabolites | Catechol metabolite |
| Elimination half-life | 17.5 hours |
| Excretion | Feces (~61%), urine (~36%)[1] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C22H19N3O4 |
| Molar mass | 389.411 g·mol−1 |
| 3D model (JSmol) | |
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Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.[3] It is a tablet taken by mouth.[3] Onset is typically within half an hour and the duration is up to 36 hours.[3]
Common side effects include headache, muscle pain, flushed skin, and nausea.[3] Caution is advised in those with cardiovascular disease.[3] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[3] Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.[3] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis with sexual arousal.[3] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[3]
Tadalafil was approved for medical use in the United States in 2003.[3] It is available as a generic medication in the United States and United Kingdom.[4] In the UK it costs the NHS about 80p per dose as of 2019.[4] In the United States the wholesale cost of this amount is about US$1.91.[5] In 2017, it was the 282nd most commonly prescribed medication in the United States, with more than one million prescriptions.[6][7]
References[edit]
- ^ "Cialis (tadalafil) Tablets, for Oral Use. Full Prescribing Information". Lilly USA, LLC. Indianapolis, IN 46285, USA. Archived from the original on 5 November 2016. Retrieved 5 November 2016.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 21 January 2021. Retrieved 8 September 2020.
- ^ a b c d e f g h i j "Tadalafil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 20 September 2020. Retrieved 8 April 2019.
- ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 796. ISBN 9780857113382.
- ^ "NADAC as of 2019-05-15". Centers for Medicare and Medicaid Services. Archived from the original on 2019-05-30. Retrieved 29 May 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
- ^ "Tadalafil - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.