User:Mr. Ibrahem/Tafluprost

Mr. Ibrahem/Tafluprost
Clinical data
Trade names	Saflutan, Taflotan, Tapros, Zioptan, others
AHFS/Drugs.com	Multum Consumer Information
Routes of; administration	Topical (eye drops)
Drug class	Prostaglandin analogue
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Metabolism	Activation by ester hydrolysis, deactivation by beta oxidation
Onset of action	2–4 hrs
Duration of action	≥ 24 hrs
Identifiers
	IUPAC name Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate;
Chemical and physical data
Formula	C25H34F2O5
Molar mass	452.539 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)OC(=O)CCC\C=C/CC(C(O)CC1O)C1\C=C\C(F)(F)COc2ccccc2;
	InChI InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1; Key:WSNODXPBBALQOF-VEJSHDCNSA-N;

Tafluprost, sold under the brand name Zioptan among others, is a medication used to treat open-angle glaucoma and ocular hypertension.^[1] It is used as an eye drop.^[1] It may be used alone or with other medications.^[1]

Common side effects include eye redness, itchiness, eyelash growth, and blurry vision.^[1] Other side effects may include iritis and macular edema.^[1] It is a prostaglandin analogue which is believed to work by increasing the outflow of aqueous fluid from the eye.^[1]

Tafluprost was approved for medical use in the United States in 2012 and Canada in 2014.^[1]^[2] In the United States it costs about 150 USD per month as of 2021.^[3] In Canada it was less cost effective as compared to bimatoprost in 2020.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Tafluprost Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 20 September 2021.
^ Canada, Health (2 July 2014). "Notice: Prescription Drug List (PDL): Multiple additions". www.canada.ca. Archived from the original on 8 July 2021. Retrieved 20 September 2021.
^ "Tafluprost Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 1 May 2016. Retrieved 20 September 2021.
^ "Prostaglandin Analogues for Ophthalmic Use: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH". www.cadth.ca. Archived from the original on 22 September 2021. Retrieved 20 September 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Tafluprost Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 20 September 2021.

[2] Canada, Health (2 July 2014). "Notice: Prescription Drug List (PDL): Multiple additions". www.canada.ca. Archived from the original on 8 July 2021. Retrieved 20 September 2021.

[3] "Tafluprost Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 1 May 2016. Retrieved 20 September 2021.

[4] "Prostaglandin Analogues for Ophthalmic Use: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH". www.cadth.ca. Archived from the original on 22 September 2021. Retrieved 20 September 2021.

[1]

[2]

[3]

[4]