User:Mr. Ibrahem/Thiamazole

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Not to be confused with metamizole, methazolamide, or methazole.

Mr. Ibrahem/Thiamazole
Clinical data
Trade namesTapazole, others
Other namesthiamazole (INN, BAN); methimazole (USAN); MMI
AHFS/Drugs.comMonograph
MedlinePlusa682464
License data
Pregnancy
category
  • D (US)
Routes of
administration		By mouth
Drug classThioamide[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability93%
Protein bindingNone
MetabolismLiver
Elimination half-life5-6 hours
ExcretionKidney
Identifiers
  • 1-Methyl-3H-imidazole-2-thione
Chemical and physical data
FormulaC4H6N2S
Molar mass114.17 g·mol−1
3D model (JSmol)
Melting point146 °C (295 °F)
Solubility in water275[2] mg/mL (20 °C)
  • Cn1cc[nH]c1=S
  • InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7) checkY
  • Key:PMRYVIKBURPHAH-UHFFFAOYSA-N checkY
  (verify)

Thiamazole, also known as methimazole, is a medication used to treat hyperthyroidism.[1] This includes Graves disease, toxic multinodular goiter, and thyrotoxic crisis.[1] It is taken by mouth.[1] Full effects may take a few weeks to occur.[4]

Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal pain.[1] Severe side effects may include low blood cell counts, liver failure, and vasculitis.[1] Use is not recommended during the first trimester of pregnancy but may be used in the second trimester or third trimester.[5] It may be used during breastfeeding.[5] Those who developed significant side effects may also have problems with propylthiouracil.[1] Thiamazole is a thioamide and works by decreasing the production of thyroid hormones.[1]

Thiamazole was approved for medical use in the United States in 1950.[1] It is on the World Health Organization's List of Essential Medicines.[6] It is available as a generic medication.[1] A month supply in the United States has a wholesale cost of about US$6.80.[7] It is also available in Europe and Asia.[8] In 2017, it was the 244th most commonly prescribed medication in the United States, with more than one million prescriptions.[9][10]

References[edit]

  1. ^ a b c d e f g h i j k l "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 July 2019. Retrieved 8 April 2019.
  2. ^ "DrugBank: Methimazole (DB00763)". drugbank.ca. Archived from the original on 15 January 2017. Retrieved 21 July 2015.
  3. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 3 December 2020. Retrieved 8 September 2020.
  4. ^ Spina, Domenico (2008). The Flesh and Bones of Medical Pharmacology E-Book. Elsevier Health Sciences. p. 74. ISBN 9780723437161. Archived from the original on 29 August 2021. Retrieved 8 April 2019.
  5. ^ a b "Methimazole Use During Pregnancy". Drugs.com. Archived from the original on 8 April 2019. Retrieved 8 April 2019.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  8. ^ Jastrzębska, Helena (2015). "Antithyroid drugs". Thyroid Research. 8 (Suppl 1): A12. doi:10.1186/1756-6614-8-S1-A12. PMC 4480840.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  10. ^ "Methimazole - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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