User:Mr. Ibrahem/Valsartan

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Mr. Ibrahem/Valsartan
Clinical data
Trade namesDiovan, others
AHFS/Drugs.comMonograph
MedlinePlusa697015
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classAngiotensin II receptor antagonist
Legal status
Legal status
Pharmacokinetic data
Bioavailability25%
Protein binding95%
Elimination half-life6 hours
ExcretionKidney 30%, biliary 70%
Identifiers
  • (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid
Chemical and physical data
FormulaC24H29N5O3
Molar mass435.528 g·mol−1
3D model (JSmol)
  • CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
  • InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 checkY
  • Key:ACWBQPMHZXGDFX-QFIPXVFZSA-N checkY
  (verify)

Valsartan, sold under the trade name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[4] It is a reasonable initial treatment for high blood pressure.[4] It is taken by mouth.[4] Versions are available as the combination valsartan/hydrochlorothiazide, valsartan/amlodipine, valsartan/amlodipine/hydrochlorothiazide, or valsartan/sacubitril.[4][5]

Common side effects include feeling tired, dizziness, high blood potassium, diarrhea, and joint pain.[4] Other serious side effects may include kidney problems, low blood pressure, and angioedema.[4] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.[6] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.[4]

Valsartan was patented in 1990, and came into medical use in 1996.[7] It is available as a generic medication.[8] A month supply in the United Kingdom costs the NHS about 5 £ per month as of 2019.[8] In the United States the wholesale cost of this amount is about US$7.50.[9] In 2017, it was the 85th most commonly prescribed medication in the United States, with more than nine million prescriptions.[10][11]

References[edit]

  1. ^ a b "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Archived from the original on 20 April 2020. Retrieved 12 February 2020.
  2. ^ "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.
  3. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 December 2020. Retrieved 6 September 2020.
  4. ^ a b c d e f g "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  5. ^ "Sacubitril and Valsartan Monograph for Professionals". Drugs.com. 7 November 2019. Archived from the original on 4 January 2020. Retrieved 12 February 2020.
  6. ^ "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 20 April 2020. Retrieved 3 March 2019.
  7. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495. Archived from the original on 12 June 2020. Retrieved 1 March 2019.
  8. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
  9. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  10. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  11. ^ "Valsartan - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
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