User:Noosentaal/Sandbox
History
[edit]Before the invention of the MDI asthma medication was delivered using a squeeze bulb nebulizer which was fragile and unreliable.[1] The relatively crude nature of these devices also meant that the particles that they generated were relatively large, too large for effective drug delivery to the lungs.[2] None the less these nebulisers paved the way for inhaltion drug delivery providing the inspiration for the MDI.
MDI's were first developed in the 1955 by Riker Laboratories, now a subsidiary of 3M Healthcare.[1] At that time MDI's represented a convergence of two relatively new technologies, the CFC propellant and the metering valve which was originally designed for dispencing perfume. The initial design by Riker used a glass canister coated with a vinyl plastic to improve it's resilience.[1] By 1956 Riker had developed two MDI based products, the Medihaler-Ept containing epinephrin and the Medihaler-Iso containing Isoprenaline.[2] Both products are β agonists which provide short term relief from asthma symptoms and have now largely been replaced in asthma treatment by salbutamol which is more selective.
References
[edit]- ^ a b c Purewal, Tol S. (1997). Metered Dose Inhaler Technology (Illustrated ed.). Informa Health Care. ISBN 1574910655.
{{cite book}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Swarbrick, James (2007). Encyclopedia of Pharmaceutical Technology (3rd Illustrated ed.). Informa Health Care. p. 1170. ISBN 978-0849393945.