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FHAD1

Forkhead-associated domain containing protein 1 (FHAD1) is a protein encoded by the FHAD1 gene.

The function of this protein is not well understood. FHAD1 has 4 aliases, Forkhead associated phosphopeptide binding domain 1, Forkhead-associated (FHA) phosphopeptide binding domain 1, FHA Domain-Containing Protein 1, and KIAA1937^[1].

In humans specifically, it is highly expressed in the testes with some expression in the lung and stomach tissues^[2].

Gene

Location

In humans, FHAD1 is located on chromosome 1 (1p36.21) and the genomic sequence starts from 15236559 bp and ends at 15400283 bp^[2].

Gene neighborhood

In humans, FHAD 1 contains 42 exons, is located on chromosome 1 or 1p36.21 and spans from 15236559 bp to 15400283 bp^[2]. It has 22 splice variants and 86 orthologues^[2].

Protein

The FHAD1 protein encoded by this gene is 16.2kDa and has 3 isoforms, namely 1, 3 and 4. It contains the following conserved regions/domains: a forkhead-associated domain that binds pSer, pThr and pTyr, two Smc regions that encode the SMC (structural maintenance of chromosome) proteins involved in replication and chromosome and chromatid segregation, and a region that encodes TMPIT-like protein annotated as being transmembrane proteins^[3].

^ Database, GeneCards Human Gene. "FHAD1 Gene - GeneCards | FHAD1 Protein | FHAD1 Antibody". www.genecards.org. Retrieved 2018-04-24.
^ ^a ^b ^c ^d "FHAD1 forkhead associated phosphopeptide binding domain 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-20.
^ "forkhead-associated domain-containing protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-20.

[1] Database, GeneCards Human Gene. "FHAD1 Gene - GeneCards | FHAD1 Protein | FHAD1 Antibody". www.genecards.org. Retrieved 2018-04-24.

[:0-2] "FHAD1 forkhead associated phosphopeptide binding domain 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-20.

[3] "forkhead-associated domain-containing protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-20.

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