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Proposed Change:

Mechanism Section – Paragraph 2, after sentence 8.

While blood-brain barrier disruption alone does appear to cause Epileptogenesis, it has been correlated to increased seizure activity.[1] Furthermore, it has been implicated in chronic epileptic conditions through experiments inducing barrier permeability with chemical compounds.[1]


Mechanism Section – Paragraph 2, after sentence 8.

Disruption may lead to fluid leaking out of the blood vessels into the area between cells and driving epileptic seizures.[2] Preliminary findings of blood proteins in the brain after a seizure support this theory.[1]

ShaunQMED (talk) 19:04, 5 November 2018 (UTC)

  1. ^ a b c van Vliet, E.A.; Aronica, E.; Gorter, J.A. (2015). "Blood–brain barrier dysfunction, seizures and epilepsy". Seminars in Cell & Developmental Biology. 38: 26–34. doi:10.1016/j.semcdb.2014.10.003. ISSN 1084-9521.
  2. ^ Marchi, Nicola; Banjara, Manoj; Janigro, Damir (2016). "Blood–brain barrier, bulk flow, and interstitial clearance in epilepsy". Journal of Neuroscience Methods. 260: 118–124. doi:10.1016/j.jneumeth.2015.06.011. ISSN 0165-0270. PMC 4835226. PMID 26093166.{{cite journal}}: CS1 maint: PMC format (link)

Comments[edit]

Thanks for sharing your suggestions. You did a nice job inserting and formatting the references. Can you add any wikilinks here? Terms only have to be linked the first time they are mentioned in an article. Is epileptogenesis linked earlier in the article? JenOttawa (talk) 16:42, 6 November 2018 (UTC)