User:Simoncaulton/Tax
Tax is a viral oncoprotein produced by the delta retrovirus human T-lymphotropic virus 1 (HTLV-1). Infection with this virus can cause a cancer known as adult t-cell leukaemia/lymphoma (ATL), largely mediated by the tax protein.[1][2]
Structure and function
[edit]Tax promotes transcription of viral and host genes. It associates with cAMP response element binding protein (CREB), a mammalian host protein that binds to the 21bp repeat on the long terminal repeat(LTR) region of the HTLV-1 DNA to activate viral DNA transcription. In addition to CREB, tax also interacts with a number of other proteins to activate the TLR, including CREB-binding protein and p300.[2] Tax also induces the
The tax protein contains a zinc binding region essential for its transactivation properties.[3] In addition, the protein requires ubiquitination, a post translational modification, for transactivation.[2]
- ^ Cassens, S.; Ulrich, U.; Beimling, P.; Simon, D. (1994 Nov). "Inhibition of human T cell leukaemia virus type I long terminal repeat expression by DNA methylation: implications for latency". The Journal of General Virology. 75 ( Pt 11) (11): 3255–9. doi:10.1099/0022-1317-75-11-3255. PMID 7964636.
{{cite journal}}: Check date values in:|date=(help) - ^ a b c Grassmann, R (2005 Sep 5). "Molecular mechanisms of cellular transformation by HTLV-1 Tax". Oncogene. 24 (39): 5976–85. doi:10.1038/sj.onc.1208978. PMID 16155604.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Semmes, O. J.; Jeang, K. T. (1992 Jun). "HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function". Virology. 188 (2): 754–64. doi:10.1016/0042-6822(92)90530-3. PMID 1585646.
{{cite journal}}: Check date values in:|date=(help)