User:Una Smith/Crystal growth inhibitor
A crystal growth inhibitor is a chemical agent that inhibits biocrystallization. These inhibitors have potential applications in medicine, in the prevention and treatment of diseases such as gout and lithiasis (kidney stones, bladder stones). Crystal growth inhibitors that are the subject of research to develop applications include chondroitin sulfate and glycosaminoglycans (GAGs) more generally, nephrocalcins, mucine.
In an area of Thailand where kidney stones are very common, a small study[1] found significant differences in glycosaminoglycans and nephrocalcins between people with stones and normal controls.
- Mucine
- Chondroitin sulfate inhibits crystal growth alone[2] and in combination with GAGs.[3]
See also: [4]
Crystal growth promoters[edit]
In vitro, growth of uric acid crystals in synovial fluid is promoted by gamma globulin.[5]
References[edit]
- ^ Nakagawa Y, Carvalho M, Malasit P; et al. (May 2004). "Kidney stone inhibitors in patients with renal stones and endemic renal tubular acidosis in northeast Thailand". Urological Research. 32 (2): 112–6. doi:10.1007/s00240-003-0389-z. PMID 14758448.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ a b c Grases F, Ramis M, Villacampa AI, Costa-Bauzá A (1999). "Uric acid urolithiasis and crystallization inhibitors". Urologia Internationalis. 62 (4): 201–4. doi:10.1159/000030395. PMID 10567882.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Grases F, Costa-Bauzá A, March JG, Masárová L (1991). "Glycosaminoglycans, uric acid and calcium oxalate urolithiasis". Urological Research. 19 (6): 375–80. doi:10.1007/BF00310153. PMID 1759332.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Terkeltaub R, Martin J, Curtiss LK, Ginsberg MH (September 1990). "Glycosaminoglycans alter the capacity of low density lipoprotein to bind to monosodium urate crystals". The Journal of Rheumatology. 17 (9): 1211–6. PMID 2290164.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ McGill NW, Dieppe PA (July 1991). "The role of serum and synovial fluid components in the promotion of urate crystal formation". The Journal of Rheumatology. 18 (7): 1042–5. PMID 1717687.
{{cite journal}}: CS1 maint: date and year (link)