User talk:Dragostanasie

References

Thank you for contributing to Wikipedia. Remember that when adding content about health, please only use high-quality reliable sources as references. We typically use review articles, major textbooks and position statements of national or international organizations (There are several kinds of sources that discuss health: here is how the community classifies them and uses them). WP:MEDHOW walks you through editing step by step. A list of resources to help edit health content can be found here. The edit box has a built-in citation tool to easily format references based on the PMID or ISBN. We also provide style advice about the structure and content of medicine-related encyclopedia articles. The welcome page is another good place to learn about editing the encyclopedia. If you have any questions, please feel free to drop me a note. Doc James (talk · contribs · email) 23:54, 23 December 2017 (UTC)[reply]

Can you find secondary sources? Thanks

Toxicity

Genotoxicity study in rats indicate chlorhexidine digluconate is able to induce primary DNA damage in leukocytes, in kidney cells^[1] and in oral mucosal cells, but no chromosome breakage or loss in reticulocytes.^[2]

Chlorhexidine is highly cytotoxic in vitro being able to induce apoptotic and autophagic/necrotic cell deaths, disturbance of mitochondrial function, intracellular Ca2+ increase and oxidative stress.^[3]

References

^ Grassi TF, Camargo EA, Salvadori DM, Marques ME, Ribeiro DA (7 March 2007). "DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats". Journal of periodontal research. 210 (2): 163–67. doi:10.1016/j.ijheh.2006.09.001. PMID 17084670.
^ Ribeiro DA, Bazo AP, da Silva Franchi CA, Marques ME, Salvadori DM (October 2004). "Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells". Journal of periodontal research. 39 (5): 358–61. doi:10.1111/j.1600-0765.2004.00759.x. PMID 15324357.
^ M. Giannelli; F. Chellini; M. Margheri; P. Tonelli; A. Tani (March 2008). "Effect of chlorhexidine digluconate on different cell types: A molecular and ultrastructural investigation". Toxicology in Vitro. 22 (2): 308–17. doi:10.1016/j.tiv.2007.09.012. PMID 17981006.

-- Doc James (talk · contribs · email) 23:39, 24 December 2017 (UTC)[reply]

What Doc James is saying is correct. We don't add content about health sourced to random primary sources like this. Please do read WP:MEDRS. Jytdog (talk) 17:26, 25 December 2017 (UTC)[reply]

Ok, so how could we keep this information even if the sources do not follow all the rules ? How about we clearly mention that more research is needed in this area and maybe rename the section to Animal Toxicty?

Dragos Tanasie (talk) 00:24, 26 December 2017 (UTC)[reply]

The second phrase can actually go on the Antiseptic section based on the rules. To quote from the WP:MEDRS "for example early in vitro results which don't hold in later clinical trials". However CHX is an antiseptic so the second phrase explains the mechanism of action in vitro (against bacteria on surfaces or surgical instruments for example). So no clinical trials would be needed for this since it is the biochemistry of the antiseptic for external use only.

Dragos Tanasie (talk) 00:43, 26 December 2017 (UTC)[reply]

Edit war warning

Your recent editing history at Chlorhexidine shows that you are currently engaged in an edit war. To resolve the content dispute, please do not revert or change the edits of others when you are reverted. Instead of reverting, please use the talk page to work toward making a version that represents consensus among editors. The best practice at this stage is to discuss, not edit-war. See BRD for how this is done. If discussions reach an impasse, you can then post a request for help at a relevant noticeboard or seek dispute resolution. In some cases, you may wish to request temporary page protection.

Being involved in an edit war can result in your being blocked from editing—especially if you violate the three-revert rule, which states that an editor must not perform more than three reverts on a single page within a 24-hour period. Undoing another editor's work—whether in whole or in part, whether involving the same or different material each time—counts as a revert. Also keep in mind that while violating the three-revert rule often leads to a block, you can still be blocked for edit warring—even if you don't violate the three-revert rule—should your behavior indicate that you intend to continue reverting repeatedly. Jytdog (talk) 17:25, 25 December 2017 (UTC)[reply]

[pmid17084670-1] Grassi TF, Camargo EA, Salvadori DM, Marques ME, Ribeiro DA (7 March 2007). "DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats". Journal of periodontal research. 210 (2): 163–67. doi:10.1016/j.ijheh.2006.09.001. PMID 17084670.

[pmid15324357-2] Ribeiro DA, Bazo AP, da Silva Franchi CA, Marques ME, Salvadori DM (October 2004). "Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells". Journal of periodontal research. 39 (5): 358–61. doi:10.1111/j.1600-0765.2004.00759.x. PMID 15324357.

[toxjournal-3] M. Giannelli; F. Chellini; M. Margheri; P. Tonelli; A. Tani (March 2008). "Effect of chlorhexidine digluconate on different cell types: A molecular and ultrastructural investigation". Toxicology in Vitro. 22 (2): 308–17. doi:10.1016/j.tiv.2007.09.012. PMID 17981006.

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